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PARD6A and PRKCG
Number of citations of the paper that reports this interaction (PMID
14676191
)
42
Data Source:
HPRD
(in vivo)
PARD6A
PRKCG
Gene Name
par-6 family cell polarity regulator alpha
protein kinase C, gamma
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Dendrite
Perinuclear Region Of Cytoplasm
Synaptic Membrane
Molecular Function
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Protein Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Serine/threonine/tyrosine Kinase Activity
ATP Binding
Zinc Ion Binding
Biological Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Protein Phosphorylation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Synaptic Transmission
Blood Coagulation
Learning Or Memory
Chemosensory Behavior
Fibroblast Growth Factor Receptor Signaling Pathway
Phosphorylation
Platelet Activation
Negative Regulation Of Protein Ubiquitination
Regulation Of Response To Food
Positive Regulation Of Mismatch Repair
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Regulation Of Circadian Rhythm
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Response To Pain
Rhythmic Process
Innervation
Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Signaling by GPCR
Ca-dependent events
CaM pathway
Phospholipase C-mediated cascade
Signaling by FGFR in disease
Signaling by Wnt
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
DAP12 signaling
Response to elevated platelet cytosolic Ca2+
G alpha (z) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by PDGF
Calmodulin induced events
DAP12 interactions
Opioid Signalling
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
Downstream signal transduction
Calmodulin induced events
WNT5A-dependent internalization of FZD4
Signaling by EGFR in Cancer
Platelet activation, signaling and aggregation
PCP/CE pathway
Transmission across Chemical Synapses
Trafficking of GluR2-containing AMPA receptors
DAG and IP3 signaling
CaM pathway
Downstream signaling of activated FGFR
Disinhibition of SNARE formation
Innate Immune System
Signalling by NGF
PLC beta mediated events
Signaling by Ligand-Responsive EGFR Variants in Cancer
G-protein mediated events
NGF signalling via TRKA from the plasma membrane
Trafficking of AMPA receptors
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
beta-catenin independent WNT signaling
PLC-gamma1 signalling
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
58 interactors:
ADRBK1
AFAP1
ANXA7
APP
ARHGEF25
CASR
CCHCR1
CD5
CDC42
CHAT
CYTH2
DAB2
DDX58
DVL2
EIF4E
EPHB1
EXOC5
GABRA1
GABRA4
GFAP
GJA1
GJA3
GRIA4
GRIN1
GRIN2B
GRIN2D
GRM5
GSK3A
HABP4
HSPA4
IRS1
ITGB2
MARK4
NFE2L2
NOXA1
NRGN
NUMB
PA2G4
PARD3
PARD6A
PARD6B
PDLIM5
PEBP1
PICK1
PNMA1
PPP1R14A
RANBP10
RGS2
SCN3A
SDC2
STXBP1
TIAM1
TOP2A
TRIM5
VTN
YWHAB
YWHAE
YWHAG
Entrez ID
50855
5582
HPRD ID
06316
01502
Ensembl ID
ENSG00000102981
ENSG00000126583
Uniprot IDs
Q9NPB6
F5H5C4
P05129
PDB IDs
1WMH
2E73
2UZP
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Regulation Of Signaling
Regulation Of Cellular Process
Signaling
Nervous System Development
Cell Communication
Cell Surface Receptor Signaling Pathway
Multicellular Organismal Development
Developmental Process
Anatomical Structure Development
Generation Of Neurons
System Development
Neuron Development
Neuron Projection Development
Neurogenesis
Signal Transduction
Positive Regulation Of Transport
Regulation Of Cellular Component Organization
Cell Differentiation
Response To Stimulus
Neuron Projection Morphogenesis
Axonogenesis
Neuron Differentiation
Regulation Of Signal Transduction
Cell Projection Organization
Cellular Response To Stimulus
Axon Development
Glutamate Receptor Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Cell Morphogenesis Involved In Neuron Differentiation
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stress
Cell-cell Signaling
Response To Organic Substance
Regulation Of Phosphorus Metabolic Process
Regulation Of Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Catalytic Activity
Cell Projection Morphogenesis
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Cell Part Morphogenesis
Ephrin Receptor Signaling Pathway
Regulation Of Cellular Localization
Cell Morphogenesis
Regulation Of Synaptic Plasticity
Axon Guidance
Positive Regulation Of Catalytic Activity
Neuron-neuron Synaptic Transmission
Transport
Regulation Of Cell Development
Tagcloud
?
apoc2
atp1a3
bckdha
cgb
cgm2
cyp2a
d19s112
d19s116
d19s117
d19s118
d19s119
d19s19
d19s2
d19s37
d19s50
d19s51
d19s54
d19s55
d19s6
d19s62
d19s63
d19s7
d19s8
d19s9
manb
pepd
psg1
pw39
tnnt1
Tagcloud (Difference)
?
apoc2
atp1a3
bckdha
cgb
cgm2
cyp2a
d19s112
d19s116
d19s117
d19s118
d19s119
d19s19
d19s2
d19s37
d19s50
d19s51
d19s54
d19s55
d19s6
d19s62
d19s63
d19s7
d19s8
d19s9
manb
pepd
psg1
pw39
tnnt1
Tagcloud (Intersection)
?