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PARD6A and PARD6B
Number of citations of the paper that reports this interaction (PMID
14676191
)
42
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
PARD6A
PARD6B
Gene Name
par-6 family cell polarity regulator alpha
par-6 family cell polarity regulator beta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Protein Binding
Biological Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Protein Complex Assembly
Cell-cell Junction Assembly
Cell Cycle
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Regulation Of Cell Migration
Cell Junction Assembly
Cell-cell Junction Organization
Cell Division
Tight Junction Assembly
Pathways
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Cell junction organization
Cell-cell junction organization
Tight junction interactions
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Bipolar disorder (
21771265
)
Protein-Protein Interactions
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
22 interactors:
APP
CDC42
CEP76
GMCL1
GOLGA2
HTRA1
MPP5
PARD3
PARD3B
PARD6A
PNMA1
PRKCG
PRKCI
PRKCZ
RAC1
RHOJ
RHOQ
TCP10
WDR83
YWHAB
YWHAH
YWHAZ
Entrez ID
50855
84612
HPRD ID
06316
18703
Ensembl ID
ENSG00000102981
ENSG00000124171
Uniprot IDs
Q9NPB6
Q9BYG5
PDB IDs
1WMH
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Cell-cell Junction Organization
Enzyme Linked Receptor Protein Signaling Pathway
Tight Junction Assembly
Regulation Of Cellular Component Organization
Membrane Organization
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apical Junction Assembly
Wound Healing
Response To Growth Factor
Platelet Activation
Positive Regulation Of Cell Death
Actin Filament-based Process
Cellular Protein Localization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Establishment Of Protein Localization
Intracellular Signal Transduction
Blood Coagulation
Regulation Of Cellular Localization
Hemostasis
Response To Wounding
Cellular Component Assembly
Regulation Of Apoptotic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transport
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Cell Death
Regulation Of Protein Localization
Cell-cell Junction Assembly
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Glucose Import
Neurogenesis
Positive Regulation Of Glucose Transport
Regulation Of Body Fluid Levels
Nervous System Development
Regulation Of Organelle Organization
Actin Cytoskeleton Organization
Defense Response
Establishment Of Golgi Localization
Neuron Development
Protein Localization To Membrane
Cellular Localization
Neuron Projection Morphogenesis
Anatomical Structure Morphogenesis
Establishment Or Maintenance Of Cell Polarity
Protein Localization
Regulation Of Glucose Import
Positive Regulation Of Mitochondrion Organization
Tagcloud
?
adm
adriamycin
arrb2
bigger
cblb
chip
cryopreservation
doubling
effectors
endoperoxide
exocytosis
exudation
gliomas
impulse
ingestion
mdr
medip
ontology
pgp
pkcalpha
rh123
sgh
snap47
tgfb1
vamp3
vamp4
verify
vps4b
wizened
Tagcloud (Difference)
?
adm
adriamycin
arrb2
bigger
cblb
chip
cryopreservation
doubling
effectors
endoperoxide
exocytosis
exudation
gliomas
impulse
ingestion
mdr
medip
ontology
pgp
pkcalpha
rh123
sgh
snap47
tgfb1
vamp3
vamp4
verify
vps4b
wizened
Tagcloud (Intersection)
?