PARD6A and WDR83

Number of citations of the paper that reports this interaction (PMID 23439680)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PARD6A	WDR83
Gene Name		par-6 family cell polarity regulator alpha	WD repeat domain 83
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell	Spliceosomal Complex Cytoplasm Catalytic Step 2 Spliceosome
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding	Protein Binding
	Biological Process	Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Maintenance Cell Division Tight Junction Assembly	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome
Pathways		Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10 TGFBR1 WDR83 YWHAH YWHAZ	17 interactors: AQR BAG2 CRB3 EGLN3 GNB2L1 GPKOW HNRNPH2 HSPB1 KDM1A KEAP1 LSM3 PARD6A PARD6B PCBP2 SAP30BP SF1 TOE1
Entrez ID		50855	84292
HPRD ID		06316	14730
Ensembl ID		ENSG00000102981	ENSG00000123154
Uniprot IDs		Q9NPB6	Q9BRX9
PDB IDs		1WMH
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Nervous System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Tight Junction Assembly Signal Transduction Regulation Of Cell Death Regulation Of Cellular Component Organization System Development Positive Regulation Of Signal Transduction Apical Junction Assembly Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cell Junction Assembly Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Programmed Cell Death Response To Growth Factor Generation Of Neurons Wound Healing Anatomical Structure Development Cellular Response To Stimulus Positive Regulation Of Cell Death Cell-cell Junction Assembly Neurogenesis Regulation Of Establishment Of Protein Localization Regulation Of Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Protein Phosphorylation Developmental Process Regulation Of Protein Localization Regulation Of Kinase Activity Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Tight Junction Assembly MRNA Processing Apical Junction Assembly MRNA Metabolic Process RNA Processing Cell-cell Junction Assembly Gene Expression Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cellular Response To Oxidative Stress RNA Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of CAMP Catabolic Process Heterocycle Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Zymogen Activation Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Primary Sex Determination Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Embryonic Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway MRNA 3'-splice Site Recognition Positive Regulation Of Endopeptidase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Female Gonad Development Nitrogen Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Peptidase Activity Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone H3-K4 Methylation
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