ECT2 and VDAC2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		ECT2	VDAC2
Gene Name		epithelial cell transforming 2	voltage-dependent anion channel 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Nucleoid Pore Complex Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Anion Transport Negative Regulation Of Protein Polymerization Regulation Of Anion Transport Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	8 interactors: ADRB2 APP BAK1 CYCS ECT2 HK1 NEDD4L RPS3A
Entrez ID		1894	7417
HPRD ID		11860	01904
Ensembl ID		ENSG00000114346	ENSG00000165637
Uniprot IDs		G5E9L8 Q9H8V3	P45880
PDB IDs		3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Positive Regulation Of Protein Metabolic Process Transport Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Response To Reactive Oxygen Species Homeostatic Process Cellular Homeostasis Positive Regulation Of Catalytic Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Binding Positive Regulation Of Proteolysis Chemical Homeostasis Negative Regulation Of Blood Pressure Apoptotic Signaling Pathway Apoptotic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Regulation Of Sodium Ion Transport Response To Stress Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Cell Death Death Regulation Of Protein Phosphorylation Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Cellular Cation Homeostasis Response To Radiation Cellular Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Metal Ion Homeostasis Response To Inorganic Substance Regulation Of Catalytic Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Systemic Arterial Blood Pressure Regulation Of Multicellular Organism Growth Regulation Of Phosphorylation Zymogen Activation Positive Regulation Of Cellular Metabolic Process Tissue Remodeling Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	adrenals carbohydrate cholesterol continues enter gonads hormonal hormones initiating interact interacts location mam mature mitochondria mitochondrial ovaries pregnenolone processed processing prolactin reproduction star steroid steroidogenesis steroidogenic terminus tom22 transports
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	adrenals carbohydrate cholesterol continues enter gonads hormonal hormones initiating interact interacts location mam mature mitochondria mitochondrial ovaries pregnenolone processed processing prolactin reproduction star steroid steroidogenesis steroidogenic terminus tom22 transports
Tagcloud (Intersection) ?