ECT2 and F2RL2

Number of citations of the paper that reports this interaction (PMID 15254234)
20

Data Source:
HPRD (in vitro, two hybrid)

		ECT2	F2RL2
Gene Name		epithelial cell transforming 2	coagulation factor II (thrombin) receptor-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Phosphatidylinositol Phospholipase C Activity Protein Binding Thrombin Receptor Activity
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Blood Coagulation Metabolic Process Response To Wounding Platelet Activation Thrombin Receptor Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	8 interactors: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3
Entrez ID		1894	2151
HPRD ID		11860	03561
Ensembl ID		ENSG00000114346	ENSG00000164220
Uniprot IDs		G5E9L8 Q9H8V3	O00254
PDB IDs		3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Cell Junction Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Junction Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Migration Tight Junction Assembly Cell Motility Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Stimulus Apical Junction Assembly Immune System Process Inflammatory Response Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Calcium Ion Transport Locomotion Regulation Of Cytoskeleton Organization Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Cell-cell Junction Assembly Movement Of Cell Or Subcellular Component Regulation Of Ion Homeostasis Positive Regulation Of Transport Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Establishment Of Endothelial Intestinal Barrier Regulation Of Cellular Component Organization Killing By Host Of Symbiont Cells Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Myeloid Progenitor Cell Differentiation Signaling Platelet Dense Granule Organization Blood Vessel Maturation
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?