ECT2 and NPC2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		ECT2	NPC2
Gene Name		epithelial cell transforming 2	Niemann-Pick disease, type C2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Lysosome Endoplasmic Reticulum Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Protein Binding Cholesterol Binding Enzyme Binding
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	7 interactors: BARD1 BRCA1 DHDDS ECT2 LIG4 PAXIP1 USP4
Entrez ID		1894	10577
HPRD ID		11860	03008
Ensembl ID		ENSG00000114346	ENSG00000119655
Uniprot IDs		G5E9L8 Q9H8V3	E7EMS2 P61916
PDB IDs		3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Response To Ionizing Radiation Protein K6-linked Ubiquitination Response To Radiation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation DNA Repair Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Cellular Response To Stress Regulation Of Protein Ubiquitination DNA Recombination Positive Regulation Of Histone Methylation Cellular Response To DNA Damage Stimulus Regulation Of Histone Acetylation Regulation Of Histone Methylation DNA Metabolic Process Regulation Of Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Histone Modification Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Signal Transduction By P53 Class Mediator Regulation Of Cell Death Regulation Of Histone Modification Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Cellular Response To Metal Ion Positive Regulation Of Protein Ubiquitination Cellular Response To Inorganic Substance Cellular Protein Modification Process Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Response To Stress Regulation Of Microtubule-based Process Protein Polyubiquitination Regulation Of Cellular Protein Metabolic Process Dolichyl Diphosphate Biosynthetic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc1 pick psen1 psen2 recessive sometimes storage trying worth
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc1 pick psen1 psen2 recessive sometimes storage trying worth
Tagcloud (Intersection) ?