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PARD6A and PRKCI
Number of citations of the paper that reports this interaction (PMID
12813044
)
67
Data Source:
HPRD
(two hybrid, in vitro)
PARD6A
PRKCI
Gene Name
par-6 family cell polarity regulator alpha
protein kinase C, iota
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Golgi Membrane
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Tight Junction
Microtubule Cytoskeleton
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Protein Complex
Intercellular Bridge
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Protein Binding
ATP Binding
Phospholipid Binding
Protein Domain Specific Binding
Metal Ion Binding
Biological Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Cellular Response To Insulin Stimulus
Cell Junction Assembly
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Glucose Import
Secretion
Neurotrophin TRK Receptor Signaling Pathway
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Response To Interleukin-1
Tight Junction Assembly
Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Cell junction organization
Cell-cell junction organization
Signalling by NGF
p75NTR recruits signalling complexes
Tight junction interactions
p75NTR signals via NF-kB
p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
41 interactors:
ADAP1
ANXA1
APP
BAD
CASP8
CDC42
CDK7
CHUK
FABP4
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MARK4
MBP
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RHOQ
SMG1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
Entrez ID
50855
5584
HPRD ID
06316
02105
Ensembl ID
ENSG00000102981
ENSG00000163558
Uniprot IDs
Q9NPB6
P41743
PDB IDs
1WMH
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Defense Response
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Immune Response
Regulation Of Cell Death
Innate Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Cellular Response To Stimulus
Regulation Of Apoptotic Process
Immune System Process
Response To Stress
Response To Stimulus
Intracellular Signal Transduction
Signaling
Cellular Response To Organic Substance
Signal Transduction
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Cell Communication
Regulation Of Cellular Protein Metabolic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of Kinase Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Organic Substance
Positive Regulation Of Programmed Cell Death
Regulation Of Phosphorylation
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Cell Death
Positive Regulation Of Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Toll-like Receptor 3 Signaling Pathway
Apoptotic Process
Response To Fibroblast Growth Factor
Negative Regulation Of Cell Death
Tagcloud
?
abcc4
aberrations
amplification
amplifications
amplified
array
azd6244
comparative
comprehensive
ctsb
erbb2
fgfr2
focal
gastric
genome
knocked
kras
mek1
met
opportunities
pak1
specimens
stard13
summary
targeted
therapeutics
whole
worldwide
worse
Tagcloud (Difference)
?
abcc4
aberrations
amplification
amplifications
amplified
array
azd6244
comparative
comprehensive
ctsb
erbb2
fgfr2
focal
gastric
genome
knocked
kras
mek1
met
opportunities
pak1
specimens
stard13
summary
targeted
therapeutics
whole
worldwide
worse
Tagcloud (Intersection)
?