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PARD6A and RHOQ
Number of citations of the paper that reports this interaction (PMID
10934474
)
205
Data Source:
HPRD
(in vitro, two hybrid)
PARD6A
RHOQ
Gene Name
par-6 family cell polarity regulator alpha
ras homolog family member Q
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Cytosol
Actin Filament
Plasma Membrane
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
GTPase Activity
Profilin Binding
GTP Binding
GBD Domain Binding
Biological Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Small GTPase Mediated Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Cell Shape
Cortical Actin Cytoskeleton Organization
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Glucose Import
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Filopodium Assembly
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Rho GTPase cycle
Signaling by Rho GTPases
Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
18 interactors:
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
COPB1
COPG1
DOCK8
EXOC7
GOPC
PARD6A
PARD6B
PFN1
PRKCI
RAPGEF1
TRIP10
TRIP6
WASL
Entrez ID
50855
23433
HPRD ID
06316
05791
Ensembl ID
ENSG00000102981
Uniprot IDs
Q9NPB6
P17081
PDB IDs
1WMH
2ATX
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Pseudopodium Assembly
Regulation Of Cell Projection Assembly
Regulation Of Cell Projection Organization
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Protein Polymerization
Positive Regulation Of Cellular Component Biogenesis
Golgi Vesicle Budding
Positive Regulation Of Protein Complex Assembly
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Membrane Budding
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Regulation Of Cytoskeleton Organization
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Regulation Of Cellular Component Size
Actin Cytoskeleton Organization
Regulation Of Cellular Component Organization
Regulation Of Protein Complex Assembly
Small GTPase Mediated Signal Transduction
Localization Within Membrane
Vesicle-mediated Transport
Actin Filament-based Process
Positive Regulation Of Hydrolase Activity
Regulation Of Cell Shape
Tight Junction Assembly
Rho Protein Signal Transduction
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Ras GTPase Activity
Cell Junction Assembly
Regulation Of GTPase Activity
Vesicle Organization
Cell-cell Junction Organization
Ras Protein Signal Transduction
Apical Junction Assembly
Organelle Organization
Positive Regulation Of Rho GTPase Activity
COPI-coated Vesicle Budding
COPI Coating Of Golgi Vesicle
Regulation Of Organelle Organization
Regulation Of Ras GTPase Activity
Golgi Vesicle Transport
Regulation Of Rho GTPase Activity
Positive Regulation Of Catalytic Activity
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Tagcloud (Intersection)
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