PARD6A and CRB3

Number of citations of the paper that reports this interaction (PMID 14718572)
55

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PARD6A	CRB3
Gene Name		par-6 family cell polarity regulator alpha	crumbs family member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell	Plasma Membrane Tight Junction Integral Component Of Membrane Apical Plasma Membrane Cell Junction Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding	SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Maintenance Cell Division Tight Junction Assembly	Cell Junction Assembly Cell-cell Junction Organization Tight Junction Assembly Protein Localization To Plasma Membrane
Pathways		Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10 TGFBR1 WDR83 YWHAH YWHAZ	5 interactors: INADL MPP5 PARD6A PSMA3 WDR83
Entrez ID		50855	92359
HPRD ID		06316	16749
Ensembl ID		ENSG00000102981	ENSG00000130545
Uniprot IDs		Q9NPB6	Q9BUF7
PDB IDs		1WMH
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Nervous System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Tight Junction Assembly Signal Transduction Regulation Of Cell Death Regulation Of Cellular Component Organization System Development Positive Regulation Of Signal Transduction Apical Junction Assembly Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cell Junction Assembly Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Programmed Cell Death Response To Growth Factor Generation Of Neurons Wound Healing Anatomical Structure Development Cellular Response To Stimulus Positive Regulation Of Cell Death Cell-cell Junction Assembly Neurogenesis Regulation Of Establishment Of Protein Localization Regulation Of Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Protein Phosphorylation Developmental Process Regulation Of Protein Localization Regulation Of Kinase Activity Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation	Tight Junction Assembly Apical Junction Assembly Cell-cell Junction Assembly Cell Junction Assembly Cell-cell Junction Organization Protein Localization To Myelin Sheath Abaxonal Region
Tagcloud ?			asymmetry complex conserved crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles scrib scribble shape suppressor transport
Tagcloud (Difference) ?			asymmetry complex conserved crumbs defective dysregulation epithelium fate focus homolog invasion kidney mainly mammary member migration mouse numerous organelle par partitioning polarity roles scrib scribble shape suppressor transport
Tagcloud (Intersection) ?