PARD6A and GLS

Number of citations: 0 (PubMedID 12629547)
Data Source: HPRD (in vivo)

		PARD6A	GLS
Name		par-6 family cell polarity regulator alpha	glutaminase
Structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Centriolar Satellite Cell Projection Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Synapse
	Molecular Function	Protein Binding GTP-dependent Protein Binding Small GTPase Binding	Glutaminase Activity Protein Binding Hydrolase Activity
	Biological Process	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome	Suckling Behavior Regulation Of Respiratory Gaseous Exchange By Nervous System Process Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Chemical Synaptic Transmission Protein Homotetramerization Intracellular Glutamate Homeostasis
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs		None	Glutamic acid
GWAS		Obesity-related traits ( 23251661 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )	Appendicular lean mass ( 33097823 ) Chronotype ( 30696823 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) JT interval (sulfonylurea treatment interaction) ( 27958378 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: ATP5MG	1 novel interactors: ARL6
Interacting Genes		27 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ SNCA TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	7 interacting genes: ATXN10 CDC42 OGT PARD6A RSPH1 SNTA1 TAX1BP3
Entrez ID		50855	2744
HPRD ID		06316	00700
Ensembl ID		ENSG00000102981	ENSG00000115419
Uniprot IDs		Q9NPB6	H7C201 O94925
PDB IDs		1WMH	3CZD 3UNW 3UO9 3VOY 3VOZ 3VP0 3VP1 3VP2 3VP3 3VP4 4O7D 5D3O 5FI2 5FI6 5FI7 5HL1 5I94 5JYO 5JYP 5U0I 5U0J 5UQE 5WJ6 6LOX 6UJG 6UJM 6UK6 6UKB 6UL9 6ULA 6ULJ 6UMC 6UMD 6UME 6UMF 7REN 7RGG 7SBM 7SBN 8BSK 8BSL 8BSM 8BSN 8GWR 8IMA 8IMB 8JUB 8JUE 8SZJ
GO Terms Enriched among Interactors		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Intracellular Signal Transduction Regulation Of Cellular Component Organization Bicellular Tight Junction PAR Polarity Complex Positive Regulation Of Cellular Component Organization Establishment Of Cell Polarity Cell-cell Junction Organization Diacylglycerol-dependent Serine/threonine Kinase Activity Cell Junction Organization Cell-cell Junction Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity Apical Part Of Cell Signal Transduction Positive Regulation Of Protein Localization Cell Cortex Tight Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Protein Localization Protein Kinase Activity Regulation Of Developmental Process Protein Phosphorylation Positive Regulation Of Cellular Component Biogenesis Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Programmed Cell Death Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Phosphorylation GBD Domain Binding Regulation Of Cell Communication Regulation Of Signaling Anchoring Junction Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytoplasm Supramolecular Fiber Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Postsynaptic Cytosol	Cell Projection Cytoskeleton GTP-dependent Protein Binding Wnt Signaling Pathway Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cytokinesis Cytoplasm GBD Domain Binding Storage Vacuole Endothelin Receptor Signaling Pathway Involved In Heart Process Protein O-acetylglucosaminyltransferase Activity Protein Transport From Ciliary Membrane To Plasma Membrane Axoneme Radial Spoke Head 1 Radial Spoke Head 3 Cell-cell Junction Organization Organelle Organization Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Division Midbody Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neuropilin Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Cellular Component Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Or Maintenance Of Cell Polarity Cytosol Syntrophin Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cilium Positive Regulation Of Protein Localization To Centrosome PAR Polarity Complex Outer Dense Fiber Radial Spoke Head Organelle Assembly Establishment Of Golgi Localization Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Protein-containing Complex