PARD6A and GLS

Number of citations of the paper that reports this interaction (PMID 12629547)
77

Data Source:
HPRD (in vivo)

		PARD6A	GLS
Gene Name		par-6 family cell polarity regulator alpha	glutaminase
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding	Glutaminase Activity Protein Binding
	Biological Process	Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Maintenance Cell Division Tight Junction Assembly	Suckling Behavior Regulation Of Respiratory Gaseous Exchange By Neurological System Process Glutamate Biosynthetic Process Glutamine Catabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Protein Homotetramerization
Pathways		Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer	Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10 TGFBR1 WDR83 YWHAH YWHAZ	4 interactors: ATXN10 PARD6A SNTA1 TAX1BP3
Entrez ID		50855	2744
HPRD ID		06316	00700
Ensembl ID		ENSG00000102981	ENSG00000115419
Uniprot IDs		Q9NPB6	O94925 Q68D38
PDB IDs		1WMH	3CZD 3UNW 3UO9 3VOY 3VOZ 3VP0 3VP1 3VP2 3VP3 3VP4
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Nervous System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Tight Junction Assembly Signal Transduction Regulation Of Cell Death Regulation Of Cellular Component Organization System Development Positive Regulation Of Signal Transduction Apical Junction Assembly Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cell Junction Assembly Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Programmed Cell Death Response To Growth Factor Generation Of Neurons Wound Healing Anatomical Structure Development Cellular Response To Stimulus Positive Regulation Of Cell Death Cell-cell Junction Assembly Neurogenesis Regulation Of Establishment Of Protein Localization Regulation Of Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Protein Phosphorylation Developmental Process Regulation Of Protein Localization Regulation Of Kinase Activity Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation	Regulation Of Vasoconstriction By Circulating Norepinephrine Negative Regulation Of Peptidyl-cysteine S-nitrosylation Negative Regulation Of Protein Localization To Cell Surface Cell-cell Junction Maintenance Activation Of Cdc42 GTPase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cdc42 GTPase Activity Regulation Of Protein Localization To Cell Surface Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Cellular Component Maintenance Regulation Of Cdc42 GTPase Activity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cdc42 Protein Signal Transduction Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Activation Of Rho GTPase Activity Regulation Of Cardiac Muscle Cell Contraction Tight Junction Assembly Neuromuscular Junction Development Activation Of Ras GTPase Activity Regulation Of Vasoconstriction Rho Protein Signal Transduction
Tagcloud ?			antigenically aphis bursa bursal conformationally d78 delaware dele delmarva ecorii georgia haeiii heptapeptide hypervariable ibdv miss mississippi pbg98 peninsula serologic southeastern spei stui styi swasasgs taqi univax vac vp2
Tagcloud (Difference) ?			antigenically aphis bursa bursal conformationally d78 delaware dele delmarva ecorii georgia haeiii heptapeptide hypervariable ibdv miss mississippi pbg98 peninsula serologic southeastern spei stui styi swasasgs taqi univax vac vp2
Tagcloud (Intersection) ?