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ECT2 and PSMA6
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
93
Data Source:
BioGRID
(two hybrid)
ECT2
PSMA6
Description
epithelial cell transforming 2
proteasome 20S subunit alpha 6
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Cell-cell Junction
Bicellular Tight Junction
Cell Cortex
Nuclear Body
Midbody
Cleavage Furrow
Anchoring Junction
Mitotic Spindle
Centralspindlin Complex
Proteasome Complex
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Proteasome Core Complex
Ribosome
Cilium
Nuclear Matrix
Proteasome Core Complex, Alpha-subunit Complex
Myofibril
Sarcomere
Extracellular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Small GTPase Binding
Protein Homodimerization Activity
RNA Binding
Endopeptidase Activity
Protein Binding
Purine Ribonucleoside Triphosphate Binding
NF-kappaB Binding
Biological Process
Mitotic Cytokinesis
Cell Morphogenesis
Nervous System Development
Protein Transport
Cell Differentiation
Activation Of Protein Kinase Activity
Positive Regulation Of Cytokinesis
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of GTPase Activity
Positive Regulation Of Neuron Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Protein Homooligomerization
Cell Division
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Cellular Response To Hydrogen Peroxide
Bicellular Tight Junction Assembly
Cellular Response To Calcium Ion
Cellular Response To Ionizing Radiation
Activation Of GTPase Activity
Positive Regulation Of Mitotic Cytokinetic Process
Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Inflammatory Response
Proteolysis Involved In Protein Catabolic Process
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
RHOA GTPase cycle
RHOB GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Obesity-related traits (
23251661
)
Red cell distribution width (
32888494
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Creatine kinase levels (
29403010
)
Psoriasis (
20953189
25903422
)
Interacting Genes
39 interacting genes:
ABR
C2orf42
CCDC91
CD19
CDK1
CHST10
CSTB
EIF4A2
EIF5B
ELOC
ERAL1
F2RL2
FANCM
GGN
HACL2
KLHL20
LAMTOR5
MBD1
MT-CO2
MT2A
NOMO1
NPC2
OOSP2
OTUB1
PARD6A
PCOLCE
PLK1
POMP
PSMA6
RACGAP1
RHOG
RPS20
SNRNP200
SPATA22
SRPK2
THAP11
UBB
USP7
VDAC2
34 interacting genes:
ALKBH4
BRCA1
BRME1
C19orf47
CADM1
CEBPA
ECT2
ERH
HSPB1
KRTAP4-2
LIG4
LIMD2
NEDD8
PAXIP1
PLK1
POLR2L
PSMA2
PSMA3
PSMA4
PSMA7
PSMC6
RNF170
RTP5
SIRPA
SMCO3
TEPSIN
TRIM39
TSPYL1
UBC
UBD
USP4
ZBTB44
ZKSCAN4
ZNF596
Entrez ID
1894
5687
HPRD ID
11860
04171
Ensembl ID
ENSG00000114346
ENSG00000100902
Uniprot IDs
Q9H8V3
A0A140VK44
P60900
PDB IDs
3L46
4N40
6L30
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSG
6MSH
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
Enriched GO Terms of Interacting Partners
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Cytosol
Positive Regulation Of Protein Monoubiquitination
Regulation Of Protein Monoubiquitination
Proteasome Core Complex, Alpha-subunit Complex
Proteasome Complex
Proteasome Core Complex
Modification-dependent Protein Catabolic Process
Nucleus
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Mitotic G2 DNA Damage Checkpoint Signaling
Proteolysis
Regulation Of Cell Cycle G2/M Phase Transition
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Mitotic G2/M Transition Checkpoint
Cellular Response To Stress
Response To Ionizing Radiation
Protein Ubiquitination
Macromolecule Catabolic Process
Signal Transduction In Response To DNA Damage
Mitotic DNA Integrity Checkpoint Signaling
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Cellular Response To Ionizing Radiation
Protein Modification By Small Protein Conjugation
Mitotic DNA Damage Checkpoint Signaling
Positive Regulation Of DNA-templated Transcription Initiation
Cellular Response To Lithium Ion
Regulation Of Canonical NF-kappaB Signal Transduction
Protein Tag Activity
Proteasomal Protein Catabolic Process
Transcription By RNA Polymerase I
Midbody
Response To Lithium Ion
Regulation Of DNA-templated Transcription Initiation
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteolysis
Double-strand Break Repair
DNA Damage Checkpoint Signaling
Regulation Of G2/M Transition Of Mitotic Cell Cycle
DNA Recombination
Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Response To Tumor Necrosis Factor
Response To Stress
Regulation Of Cell Cycle Phase Transition
Identical Protein Binding
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Negative Regulation Of Protein Kinase C Signaling
Establishment Of Integrated Proviral Latency
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