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PARD6A and MARK2
Number of citations of the paper that reports this interaction (PMID
14676191
)
42
Data Source:
HPRD
(in vivo)
PARD6A
MARK2
Gene Name
par-6 family cell polarity regulator alpha
MAP/microtubule affinity-regulating kinase 2
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Nucleus
Mitochondrion
Actin Filament
Plasma Membrane
Membrane
Lateral Plasma Membrane
Basal Cortex
Microtubule Bundle
Molecular Function
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Lipid Binding
Protein Kinase Activator Activity
Poly(A) RNA Binding
Tau-protein Kinase Activity
Biological Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Mitochondrion Degradation
Neuron Migration
Protein Phosphorylation
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Peptidyl-threonine Phosphorylation
Establishment Of Cell Polarity
Activation Of Protein Kinase Activity
Intracellular Signal Transduction
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Protein Autophosphorylation
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Mitochondrion Localization
Pathways
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
23 interactors:
BAIAP2
CAMK1
DVL3
GAB1
GSK3B
HDAC7
KIF13B
MAP3K3
MAPT
MTCL1
NEDD4
NEDD4L
PARD6A
PINK1
PKD1
PRKCE
RAB11FIP2
RNF41
STK11
UTRN
YWHAB
YWHAQ
YWHAZ
Entrez ID
50855
2011
HPRD ID
06316
02753
Ensembl ID
ENSG00000102981
ENSG00000072518
Uniprot IDs
Q9NPB6
A8K2S4
Q7KZI7
PDB IDs
1WMH
3IEC
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Regulation Of Cellular Component Organization
Regulation Of Cellular Localization
Regulation Of Intracellular Transport
Signaling
Positive Regulation Of Signal Transduction
Cell Communication
Positive Regulation Of Transport
Signal Transduction
Positive Regulation Of Intracellular Transport
Positive Regulation Of Mitochondrion Organization
Positive Regulation Of Organelle Organization
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Positive Regulation Of Protein Kinase Activity
Regulation Of Signaling
Regulation Of Phosphorylation
Positive Regulation Of Kinase Activity
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Regulation Of Kinase Activity
Regulation Of Protein Localization
Regulation Of Mitochondrion Organization
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Transferase Activity
Cellular Response To Organic Substance
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Catalytic Activity
Regulation Of Neuron Projection Development
Negative Regulation Of Transport
Regulation Of MAPK Cascade
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Organelle Organization
Positive Regulation Of Protein Modification Process
Negative Regulation Of Sodium Ion Transport
Regulation Of Establishment Of Protein Localization
Apoptotic Process
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Programmed Cell Death
Regulation Of Cell Projection Organization
Cell Death
Death
Response To Stimulus
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Regulation Of Sodium Ion Transport
Tagcloud
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adjusting
aor
assisted
backgroundlimited
children
china
conclusionsscreen
habits
height
hrs
inverted
lifestyle
mark0
methodsa
modes
multilevel
obese
obesity
overweight
question
questions
results15
school
schools
screen
spent
travel
Tagcloud (Difference)
?
adjusting
aor
assisted
backgroundlimited
children
china
conclusionsscreen
habits
height
hrs
inverted
lifestyle
mark0
methodsa
modes
multilevel
obese
obesity
overweight
question
questions
results15
school
schools
screen
spent
travel
Tagcloud (Intersection)
?