ECT2 and CSTB

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		ECT2	CSTB
Description		epithelial cell transforming 2	cystatin B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Adult Locomotory Behavior Negative Regulation Of Proteolysis
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Neutrophil degranulation
Drugs			Cupric Chloride
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2	8 interacting genes: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1894	1476
HPRD ID		11860	03091
Ensembl ID		ENSG00000114346	ENSG00000160213
Uniprot IDs		Q9H8V3	P04080 Q76LA1
PDB IDs		3L46 4N40 6L30	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?		Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination	Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Ficolin-1-rich Granule Lumen Extracellular Matrix Endolysosome Lumen Tertiary Granule Lumen Lysosome Regulation Of Extracellular Matrix Organization Collagen Binding Collagen Metabolic Process Endopeptidase Activity Proteoglycan Binding Antigen Processing And Presentation Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Lung Morphogenesis Peptidase Activity Regulation Of Programmed Cell Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Zymogen Activation Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Regulation Of Collagen Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Tissue Regeneration Response To Polyamine Macromolecule Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process ERK1 And ERK2 Cascade HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Developmental Process Antigen Processing And Presentation Of Peptide Antigen Extracellular Exosome Extracellular Region Regulation Of Tissue Remodeling Multicellular Organismal Locomotion Negative Regulation Of Blood Vessel Remodeling Cellular Response To Hormone Stimulus Aspartic-type Peptidase Activity Kininogen Binding Enkephalin Processing Lung Growth Extracellular Space Lysosomal Lumen
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