ECT2 and PCOLCE

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		ECT2	PCOLCE
Gene Name		epithelial cell transforming 2	procollagen C-endopeptidase enhancer
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Proteolysis Multicellular Organismal Development Positive Regulation Of Peptidase Activity
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Collagen formation Crosslinking of collagen fibrils Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	4 interactors: COL2A1 COL3A1 ECT2 PLG
Entrez ID		1894	5118
HPRD ID		11860	02603
Ensembl ID		ENSG00000114346	ENSG00000106333
Uniprot IDs		G5E9L8 Q9H8V3	Q15113
PDB IDs		3L46	1UAP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Cell Morphogenesis Platelet Activation Cell Differentiation Mononuclear Cell Migration Locomotion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Aorta Smooth Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Regulation Of Rho Protein Signal Transduction Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Negative Regulation Of Fibrinolysis Catabolic Process Multicellular Organismal Development Blood Coagulation Anatomical Structure Development Cellular Response To Organic Substance Hemostasis Extracellular Fibril Organization Response To Radiation Activation Of Rac GTPase Activity Regulation Of Fibrinolysis Embryonic Organ Development Muscle Structure Development Blood Vessel Development Heart Development Otic Vesicle Development Axonogenesis Developmental Process Vasculature Development Positive Regulation Of Cdc42 GTPase Activity Skeletal System Development Embryonic Skeletal Joint Morphogenesis Trophoblast Giant Cell Differentiation
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	apolipoprotein cathepsin cerebrospinal csf dbp dismutase electrophoresis electrospray endopeptidase epilepsy epileptogenesis fam3c igkv1 igl immunoglobulin ionization lambda lobe pathophysiologic proteomic sod1 spots superoxide talin tandem tetranectin tle tn
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	apolipoprotein cathepsin cerebrospinal csf dbp dismutase electrophoresis electrospray endopeptidase epilepsy epileptogenesis fam3c igkv1 igl immunoglobulin ionization lambda lobe pathophysiologic proteomic sod1 spots superoxide talin tandem tetranectin tle tn
Tagcloud (Intersection) ?