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PARD6A and PLCB3
Number of citations of the paper that reports this interaction (PMID
15782111
)
7
Data Source:
HPRD
(in vivo)
PARD6A
PLCB3
Gene Name
par-6 family cell polarity regulator alpha
phospholipase C, beta 3 (phosphatidylinositol-specific)
Image
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Nucleoplasm
Cytosol
Membrane
Protein Complex
Molecular Function
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Signal Transducer Activity
Calcium Ion Binding
Calmodulin Binding
Biological Process
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Regulation Of Systemic Arterial Blood Pressure
Synaptic Transmission
Lipid Catabolic Process
Intracellular Signal Transduction
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
G alpha (q) signalling events
Signaling by GPCR
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Integration of energy metabolism
G beta:gamma signalling through PLC beta
Signaling by Wnt
Synthesis of IP3 and IP4 in the cytosol
Gastrin-CREB signalling pathway via PKC and MAPK
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
PLC beta mediated events
G-protein beta:gamma signalling
Opioid Signalling
Regulation of insulin secretion
G-protein mediated events
Activation of Kainate Receptors upon glutamate binding
Inositol phosphate metabolism
beta-catenin independent WNT signaling
Presynaptic function of Kainate receptors
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Ca2+ pathway
Free fatty acids regulate insulin secretion
Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
13 interactors:
CALM3
CAMK2B
CAMK2G
FOXE1
KRIT1
PARD3
PARD6A
PRKG1
PRKG2
RGS12
SLC9A3R2
TRPC3
TRPM7
Entrez ID
50855
5331
HPRD ID
06316
02577
Ensembl ID
ENSG00000102981
ENSG00000149782
Uniprot IDs
Q9NPB6
Q01970
PDB IDs
1WMH
3OHM
4GNK
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Regulation Of Calcium Ion Transport
Protein Autophosphorylation
Regulation Of Skeletal Muscle Adaptation
Wound Healing
Calcium Ion Transport
Response To Wounding
Signal Transduction
Negative Regulation Of Peptidyl-threonine Phosphorylation
Blood Coagulation
Hemostasis
Signaling
Cell Communication
Nitric Oxide Metabolic Process
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Cellular Response To Heat
Reactive Nitrogen Species Metabolic Process
Regulation Of Nitric-oxide Synthase Activity
Regulation Of Body Fluid Levels
Phosphorylation
Regulation Of Ion Transport
Tight Junction Assembly
Cellular Response To Stimulus
Protein Phosphorylation
System Development
Inhibitory G-protein Coupled Receptor Phosphorylation
Cellular Response To Heat
Response To Metal Ion
Nervous System Development
Apical Junction Assembly
Regulation Of Oxidoreductase Activity
Metal Ion Transport
Regulation Of Calcium Ion Transport Into Cytosol
Response To Stress
Pharynx Development
Activation Of Meiosis Involved In Egg Activation
Positive Regulation Of Calcium Ion Transport
Multicellular Organismal Development
Phototransduction
Response To Organic Substance
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Anatomical Structure Development
Detection Of Light Stimulus
Response To Heat
Reactive Oxygen Species Metabolic Process
Regulation Of Cellular Process
Response To Calcium Ion
Peptidyl-serine Phosphorylation
Cell-cell Junction Assembly
Response To Inorganic Substance
Interferon-gamma-mediated Signaling Pathway
Tagcloud
?
calpain
candidate
candidates
capn1
chuk
compelling
consideration
defect
disorder
distally
encode
fatal
harlequin
hi
ichq
ichthyosis
ikka
keratinocytes
locus
mapping
mutational
narrowed
phospholipase
r433p
refined
rela
scaling
similarities
unrelated
Tagcloud (Difference)
?
calpain
candidate
candidates
capn1
chuk
compelling
consideration
defect
disorder
distally
encode
fatal
harlequin
hi
ichq
ichthyosis
ikka
keratinocytes
locus
mapping
mutational
narrowed
phospholipase
r433p
refined
rela
scaling
similarities
unrelated
Tagcloud (Intersection)
?