PARD6A and PLCB3

Number of citations of the paper that reports this interaction (PubMedID 15782111)
0

Data Source:
HPRD (in vivo)

		PARD6A	PLCB3
Description		par-6 family cell polarity regulator alpha	phospholipase C beta 3
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Centriolar Satellite Cell Projection Tight Junction Anchoring Junction PAR Polarity Complex	Nucleus Cytoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol
	Molecular Function	Protein Binding GTP-dependent Protein Binding Small GTPase Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Cadherin Binding Molecular Adaptor Activity Phosphatidylinositol Phospholipase C Activity Molecular Function Activator Activity
	Biological Process	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome	Regulation Of Systemic Arterial Blood Pressure Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		27 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ SNCA TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 NHERF2 PARD3 PARD6A PRKG1 PRKG2 RGS12 TRPC3 TRPM7
Entrez ID		50855	5331
HPRD ID		06316	02577
Ensembl ID		ENSG00000102981	ENSG00000149782
Uniprot IDs		Q9NPB6	Q01970
PDB IDs		1WMH	4GNK 4QJ3 4QJ4 4QJ5 7SQ2 8EMV 8EMW 8EMX 8UQN 8UQO
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Intracellular Signal Transduction Regulation Of Cellular Component Organization Bicellular Tight Junction PAR Polarity Complex Positive Regulation Of Cellular Component Organization Establishment Of Cell Polarity Cell-cell Junction Organization Diacylglycerol-dependent Serine/threonine Kinase Activity Cell Junction Organization Cell-cell Junction Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity Apical Part Of Cell Signal Transduction Positive Regulation Of Protein Localization Cell Cortex Tight Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Protein Localization Protein Kinase Activity Regulation Of Developmental Process Protein Phosphorylation Positive Regulation Of Cellular Component Biogenesis Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Programmed Cell Death Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Phosphorylation GBD Domain Binding Regulation Of Cell Communication Regulation Of Signaling Anchoring Junction Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytoplasm Supramolecular Fiber Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Postsynaptic Cytosol	Regulation Of Muscle System Process CGMP-dependent Protein Kinase Activity Type 3 Metabotropic Glutamate Receptor Binding Regulation Of System Process Protein Serine Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transport Protein Serine/threonine Kinase Activity PAR Polarity Complex Regulation Of Calcium Ion Transport Protein Kinase Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Transport Kinase Activity CGMP Binding Regulation Of Metal Ion Transport Protein Phosphorylation Calcium/calmodulin-dependent Protein Kinase Activity Apical Plasma Membrane Phosphorylation Positive Regulation Of Synaptic Transmission GTPase Regulator Activity Plasma Membrane Tight Junction Sarcoplasmic Reticulum Membrane Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Localization Within Membrane Regulation Of Cellular Localization Calcium Channel Regulator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Chloride Transport Type 2 Metabotropic Glutamate Receptor Binding Calcium-dependent Cell-matrix Adhesion Calcium Channel Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Chordate Pharynx Development Negative Regulation Of Monoatomic Ion Transport ATP Binding Ruffle Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation
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