DLG3 and ADGRL1

Number of citations of the paper that reports this interaction (PubMedID 10958799)
0

Data Source:
HPRD (two hybrid)

		DLG3	ADGRL1
Description		discs large MAGUK scaffold protein 3	adhesion G protein-coupled receptor L1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Neuron Projection Synapse
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	L1-L4 bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	10 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2 SHANK3
Entrez ID		1741	22859
HPRD ID		02177	14305
Ensembl ID		ENSG00000082458	ENSG00000072071
Uniprot IDs		Q59FY1 Q92796	O94910
PDB IDs		1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Ionotropic Glutamate Receptor Binding Vocalization Behavior Synaptic Receptor Adaptor Activity Neuron Projection Social Behavior Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Dendritic Spine Learning Neuron Projection Organization Postsynapse Organization Receptor Clustering Neuromuscular Process Controlling Balance AMPA Glutamate Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Protein Localization To Synapse Postsynaptic Membrane Scaffold Protein Binding Neuron Spine Postsynaptic Density Learning Or Memory Protein Localization To Cell Junction Associative Learning Cognition Cell Projection Neurotransmitter-gated Ion Channel Clustering Neuromuscular Process SH3 Domain Binding Regulation Of Nervous System Process Postsynaptic Density Organization Positive Regulation Of Synaptic Transmission Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Synapse Postsynaptic Specialization Organization Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Adherens Junction Regulation Of Synaptic Plasticity Developmental Maturation Negative Regulation Of Actin Filament Bundle Assembly Nervous System Development Positive Regulation Of Dendritic Spine Development Ligand-gated Ion Channel Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?