DLG3 and GDA

Number of citations of the paper that reports this interaction (PMID 10595517)
23

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DLG3	GDA
Gene Name		discs, large homolog 3 (Drosophila)	guanine deaminase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane	Intracellular Cytosol Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Zinc Ion Binding Guanine Deaminase Activity
	Biological Process	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Guanine Catabolic Process Purine Nucleotide Catabolic Process Nervous System Development Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Purine catabolism Purine metabolism Metabolism of nucleotides
Drugs
Diseases
GWAS			Suicidal ideation ( 20877300)
Protein-Protein Interactions		40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1	4 interactors: DLG1 DLG3 DLG4 SNTA1
Entrez ID		1741	9615
HPRD ID		02177	08849
Ensembl ID		ENSG00000082458	ENSG00000119125
Uniprot IDs		Q59FY1 Q92796	Q9Y2T3
PDB IDs		1UM7 2FE5 2I1N	2UZ9 3E0L 4AQL
Enriched GO Terms of Interacting Partners?		Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization	Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Nucleotide Phosphorylation Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Membrane Potential Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Protein Localization To Membrane Axon Guidance Regulation Of Ion Transmembrane Transport Axonogenesis Regulation Of Sodium Ion Transport Nucleotide Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Vasoconstriction By Circulating Norepinephrine Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cell-cell Signaling Neuron Development Synapse Organization Organophosphate Metabolic Process Cell Morphogenesis Neuron Differentiation Cell Projection Organization Muscle Contraction Locomotion Muscle System Process Cellular Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Movement Of Cell Or Subcellular Component Maintenance Of Apical/basal Cell Polarity Generation Of Neurons Neurogenesis
Tagcloud ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	bare demand desolvation destructive directions electrospray enter equipped esi grids guide guides heating instrument lasers masses nanoparticle particle particles pass passage paul photons pumping quadrupole scattered separating spraying tem
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	bare demand desolvation destructive directions electrospray enter equipped esi grids guide guides heating instrument lasers masses nanoparticle particle particles pass passage paul photons pumping quadrupole scattered separating spraying tem
Tagcloud (Intersection) ?