DLG3 and GRIK2

Number of citations of the paper that reports this interaction (PMID 9808460)
38

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DLG3	GRIK2
Gene Name		discs, large homolog 3 (Drosophila)	glutamate receptor, ionotropic, kainate 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity
	Biological Process	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Behavioral Fear Response Transport Cellular Calcium Ion Homeostasis Intracellular Protein Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential
Pathways		Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Activation of Na-permeable Kainate Receptors Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Domoic Acid Quisqualate 2s,4r-4-Methylglutamate
Diseases
GWAS			Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) plasma levels ( 23362303) Renal function-related traits (eGRFcrea) ( 22797727)
Protein-Protein Interactions		40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1	18 interactors: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25
Entrez ID		1741	2898
HPRD ID		02177	00692
Ensembl ID		ENSG00000082458	ENSG00000164418
Uniprot IDs		Q59FY1 Q92796	A8K0H7 F8WEZ8 Q13002 Q8IY40
PDB IDs		1UM7 2FE5 2I1N	3QXM
Enriched GO Terms of Interacting Partners?		Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization	Synaptic Transmission Cell-cell Signaling Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Signaling Cell Communication Receptor Localization To Synapse Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Nucleotide Phosphorylation Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Protein Localization Protein Localization Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Differentiation Signal Transduction Neurogenesis Nervous System Development Membrane Organization Response To External Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Generation Of Neurons Establishment Or Maintenance Of Cell Polarity Maintenance Of Apical/basal Cell Polarity Cell Junction Assembly Negative Regulation Of Signaling Cellular Response To Stimulus Cell-cell Junction Organization Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Localization Cell Development Regulation Of Postsynaptic Membrane Potential Response To Stimulus Adherens Junction Organization Maintenance Of Cell Polarity Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Membrane Potential Wnt Signaling Pathway Neuron Development Positive Regulation Of Metabolic Process Regulation Of Synaptic Transmission Regulation Of Cellular Process Long Term Synaptic Depression
Tagcloud ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	ancestry approaching asd asds autism candidate decade dutch failing finnish goldengate illumina intractable linkage mkl2 mlod reln replicate rs1881084 rs2518261 rs2885116 rs362780 rs756472 snd1 snp strengthen strengthened strict suggestive
Tagcloud (Intersection) ?