DLG3 and CRIPT

Number of citations of the paper that reports this interaction (PubMedID 12070168)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DLG3	CRIPT
Description		discs large MAGUK scaffold protein 3	CXXC repeat containing interactor of PDZ3 domain
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Spliceosomal Complex Cytoplasm Postsynaptic Density Dendrite Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Protein Binding Microtubule Binding PDZ Domain Binding Protein-containing Complex Binding Scaffold Protein Binding
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	MRNA Processing RNA Splicing Cytoplasmic Microtubule Organization Protein Localization To Microtubule Regulation Of Postsynaptic Density Assembly Regulation Of Postsynaptic Density Protein 95 Clustering
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20966902) Pulse pressure (alcohol consumption interaction) ( 24376456) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	9 interacting genes: CEBPA DLG1 DLG2 DLG3 DLG4 PATJ SNCA TUBB UBQLN4
Entrez ID		1741	9419
HPRD ID		02177	05208
Ensembl ID		ENSG00000082458	ENSG00000119878
Uniprot IDs		Q59FY1 Q92796	Q9P021
PDB IDs		1UM7 2FE5 2I1N	7DVQ
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Kinase Binding Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Protein Localization To Cell Junction Postsynaptic Density Membrane Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Cellular Response To Metal Ion Adherens Junction Cell-cell Signaling Signaling GMP Kinase Activity Cell Communication Protein Localization To Membrane GDP Metabolic Process Response To Metal Ion Juxtaparanode Region Of Axon Neuron Projection Cellular Response To Potassium Ion Bicellular Tight Junction Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To Potassium Ion Protein Kinase Binding Cell-cell Adhesion Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex GMP Metabolic Process Localization Within Membrane Protein Localization To Postsynaptic Membrane Cell Junction Protein Localization To Postsynapse Nervous System Development Protein Domain Specific Binding Basolateral Plasma Membrane Postsynaptic Density Perinuclear Region Of Cytoplasm Tight Junction Assembly Phosphatase Binding Tight Junction Organization Regulation Of Macrophage Activation Protein-containing Complex Regulation Of Neuronal Synaptic Plasticity
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