ADGRL1 and SHANK3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		ADGRL1	SHANK3
Description		adhesion G protein-coupled receptor L1	SH3 and multiple ankyrin repeat domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Neuron Projection Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins RET signaling
Drugs
Diseases
GWAS		L1-L4 bone mineral density x serum urate levels interaction ( 34046847)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		10 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2 SHANK3	152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2
Entrez ID		22859	85358
HPRD ID		14305	18979
Ensembl ID		ENSG00000072071	ENSG00000251322
Uniprot IDs		O94910	Q9BYB0
PDB IDs			6CPK 7C7I 7C7J
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Vocalization Behavior Synaptic Receptor Adaptor Activity Neuron Projection Social Behavior Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Dendritic Spine Learning Neuron Projection Organization Postsynapse Organization Receptor Clustering Neuromuscular Process Controlling Balance AMPA Glutamate Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Protein Localization To Synapse Postsynaptic Membrane Scaffold Protein Binding Neuron Spine Postsynaptic Density Learning Or Memory Protein Localization To Cell Junction Associative Learning Cognition Cell Projection Neurotransmitter-gated Ion Channel Clustering Neuromuscular Process SH3 Domain Binding Regulation Of Nervous System Process Postsynaptic Density Organization Positive Regulation Of Synaptic Transmission Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Synapse Postsynaptic Specialization Organization Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Adherens Junction Regulation Of Synaptic Plasticity Developmental Maturation Negative Regulation Of Actin Filament Bundle Assembly Nervous System Development Positive Regulation Of Dendritic Spine Development Ligand-gated Ion Channel Signaling Pathway	Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization
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