DLG3 and SCN5A

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		DLG3	SCN5A
Gene Name		discs, large homolog 3 (Drosophila)	sodium channel, voltage gated, type V alpha subunit
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane	Voltage-gated Sodium Channel Complex Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Voltage-gated Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Scaffold Protein Binding
	Biological Process	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Axon Guidance Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport
Pathways		Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs			Indecainide Ranolazine Phenytoin Disopyramide Lidocaine Mexiletine Hexylcaine Dibucaine Mephenytoin Carbamazepine Verapamil Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine
Diseases
GWAS			Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 20062063) PR interval ( 20062060 23139255 21347284) QT interval ( 19305408 19305409) Ventricular conduction ( 21076409)
Protein-Protein Interactions		40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1	17 interactors: CALM1 CBL CDK2 DLG1 DLG2 DLG3 DLG4 INADL NEDD4 NEDD4L RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 WWP2
Entrez ID		1741	6331
HPRD ID		02177	02543
Ensembl ID		ENSG00000082458	ENSG00000183873
Uniprot IDs		Q59FY1 Q92796	E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90
PDB IDs		1UM7 2FE5 2I1N	2KBI 2L53 4DCK 4DJC
Enriched GO Terms of Interacting Partners?		Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization	Receptor Localization To Synapse Protein Localization To Synapse Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Receptor Clustering Nucleotide Phosphorylation Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle System Process Regulation Of Potassium Ion Transmembrane Transporter Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Sodium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Muscle Contraction Negative Regulation Of Sodium Ion Transport Synaptic Transmission Regulation Of Protein Metabolic Process Negative Regulation Of Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Catalytic Activity Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Signaling Protein Localization To Membrane Regulation Of Dephosphorylation Positive Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Signal Transduction Cortical Cytoskeleton Organization Membrane Organization Protein Polyubiquitination Synapse Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein K63-linked Ubiquitination
Tagcloud ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge
Tagcloud (Intersection) ?