DLG3 and AOAH

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		DLG3	AOAH
Name		discs large MAGUK scaffold protein 3	acyloxyacyl hydrolase
Structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Cytoplasmic Vesicle
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Calcium Ion Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Metal Ion Binding Acyloxyacyl Hydrolase Activity
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Lipid Metabolic Process Fatty Acid Metabolic Process Lipopolysaccharide Metabolic Process Lipopolysaccharide Catabolic Process Negative Regulation Of Inflammatory Response
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	None
Diseases		Non-syndromic X-linked mental retardation	None
GWAS		Mean platelet volume ( 32888494 )	Atypical femoral fracture in phosphonate treatment ( 31006051 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Corneal astigmatism ( 30306274 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HIV-1 viral setpoint ( 20205591 ) Obesity-related traits ( 23251661 )
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	2 interacting genes: DLG2 DLG3
Entrez ID		1741	313
HPRD ID		02177	00027
Ensembl ID		ENSG00000082458	ENSG00000136250
Uniprot IDs		Q59FY1 Q92796	A0A087WVT3 P28039
PDB IDs		1UM7 2FE5 2I1N	5W78 5W7C
GO Terms Enriched among Interactors		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Receptor Clustering Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Protein Localization To Cell Junction Kinase Binding Postsynaptic Density Membrane Establishment Or Maintenance Of Cell Polarity Adherens Junction Basolateral Plasma Membrane Retrograde Axonal Protein Transport Chemical Synaptic Transmission Protein Localization To Membrane Neuron Projection Trans-synaptic Signaling Synaptic Signaling Protein Kinase Binding Cell-cell Adhesion GMP Kinase Activity Localization Within Membrane Anterograde Axonal Protein Transport Nervous System Development Cell-cell Signaling GDP Metabolic Process Signaling Juxtaparanode Region Of Axon Cell Communication Protein Transport Along Microtubule Cellular Response To Potassium Ion Response To Potassium Ion Retrograde Axonal Transport Cell Adhesion Establishment Of Planar Polarity AMPA Glutamate Receptor Complex GMP Metabolic Process System Development Anterograde Axonal Transport Phosphatase Binding Axon Cytoplasm Axonal Transport Cellular Localization Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex Axo-dendritic Transport Nucleoside Diphosphate Metabolic Process