LPHN1 and ROS1

Number of citations of the paper that reports this interaction (PMID 10958799)
9

Data Source:
HPRD (two hybrid)

		LPHN1	ROS1
Gene Name		latrophilin 1	ROS proto-oncogene 1 , receptor tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules G-protein Coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation	Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Growth Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of TOR Signaling Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778)	Lung cancer ( 23143601) QT interval (interaction) ( 23459443)
Protein-Protein Interactions		9 interactors: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2	6 interactors: ABL1 IKBKG LPHN1 PTPN11 PTPN6 VAV3
Entrez ID		22859	6098
HPRD ID		14305	01295
Ensembl ID			ENSG00000047936
Uniprot IDs		O94910	P08922
PDB IDs			3ZBF
Enriched GO Terms of Interacting Partners?		Vocalization Behavior Protein Localization To Synapse Synapse Organization Neuron Development Social Behavior Cell Development Receptor Clustering Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Nervous System Development Neuromuscular Process Controlling Balance Synapse Assembly Cell Morphogenesis Involved In Differentiation Receptor Localization To Synapse Dendrite Morphogenesis Neuron Projection Development Generation Of Neurons Cell Projection Morphogenesis Dendritic Spine Morphogenesis Cell Part Morphogenesis Neurogenesis Membrane Depolarization Neuromuscular Process Single-organism Behavior Learning Dendritic Spine Development Dendrite Development Regulation Of Signaling Cell Morphogenesis Dendritic Spine Organization Anatomical Structure Development Adult Behavior Reflex Cell Projection Organization Cell Differentiation Exploration Behavior Synaptic Transmission Behavior Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transport Developmental Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Signaling Cell Communication Positive Regulation Of Membrane Potential Learning Or Memory Regulation Of Membrane Potential System Development Cognition	Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Abortive Mitotic Cell Cycle B Cell Receptor Signaling Pathway Regulation Of Kinase Activity Fc Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Defense Response Regulation Of Body Fluid Levels Megakaryocyte Development Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Regulation Of MAPK Cascade Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Formation Response To Wounding Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Negative Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Cell Migration Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility B Cell Homeostasis Regulation Of MAP Kinase Activity
Tagcloud ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e
Tagcloud (Difference) ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e
Tagcloud (Intersection) ?