DLG3 and CNKSR2

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		DLG3	CNKSR2
Gene Name		discs, large homolog 3 (Drosophila)	connector enhancer of kinase suppressor of Ras 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane	Golgi Apparatus Plasma Membrane Neuron Projection Neuronal Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Identical Protein Binding
	Biological Process	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Regulation Of Signal Transduction
Pathways		Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1	12 interactors: DLG1 DLG2 DLG3 DLG4 INADL LRRC7 RALA RGS3 SHANK3 SNTA1 TJP1 TNIK
Entrez ID		1741	22866
HPRD ID		02177	06473
Ensembl ID		ENSG00000082458	ENSG00000149970
Uniprot IDs		Q59FY1 Q92796	B3KPN2 Q8WXI2
PDB IDs		1UM7 2FE5 2I1N	2EAN 3BS5
Enriched GO Terms of Interacting Partners?		Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization	Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Membrane Organization Protein Localization To Membrane Nucleotide Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cellular Protein Localization Vocalization Behavior Cell-cell Junction Assembly Cellular Localization Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Organization Cortical Actin Cytoskeleton Organization Response To External Stimulus Postsynaptic Membrane Organization Establishment Or Maintenance Of Cell Polarity Phosphorylation Cortical Cytoskeleton Organization Signaling Cellular Component Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization Cytoskeleton Organization Nucleotide Metabolic Process Cell Junction Assembly Cell Communication Cell Projection Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Cell-cell Junction Organization Chemotaxis Actin Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Neuron Projection Morphogenesis Social Behavior Actin Filament-based Process Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Membrane Potential Tight Junction Assembly Cell Morphogenesis Involved In Differentiation
Tagcloud ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?