DLG3 and CACNG2

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		DLG3	CACNG2
Description		discs large MAGUK scaffold protein 3	calcium voltage-gated channel auxiliary subunit gamma 2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Monoatomic Ion Channel Complex Somatodendritic Compartment Neuron Projection Organelle Cerebellar Mossy Fiber Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Channel Regulator Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Protein Targeting To Membrane Monoatomic Ion Transport Calcium Ion Transport Neuromuscular Junction Development Transmission Of Nerve Impulse Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Response To Calcium Ion Membrane Depolarization Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Hyperpolarization Eye Blink Reflex Calcium Ion Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions
Drugs			Ergocalciferol Enflurane Spironolactone Nicardipine Verapamil Ethanol Efonidipine Butamben Bioallethrin
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Daytime nap ( 33568662)
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	11 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2 WIPF1
Entrez ID		1741	10369
HPRD ID		02177	04220
Ensembl ID		ENSG00000082458	ENSG00000166862
Uniprot IDs		Q59FY1 Q92796	Q9Y698
PDB IDs		1UM7 2FE5 2I1N	6DLZ 6DM0 6DM1 6O9G 6TNO
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Neuromuscular Junction Postsynaptic Density Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Cell Communication AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Ligand-gated Ion Channel Signaling Pathway Cell-cell Signaling Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Neuron Projection Signaling Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Synaptic Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Kinase Binding Protein Localization To Cell Junction Kinase Binding Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Cell Projection Modulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Adherens Junction NMDA Selective Glutamate Receptor Signaling Pathway AMPA Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission Synapse Postsynapse Presynapse Neuron Spine Endocytic Vesicle Membrane GMP Kinase Activity Regulation Of System Process Postsynaptic Density Glutamatergic Synapse Cellular Component Assembly Glutamate-gated Receptor Activity GDP Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Juxtaparanode Region Of Axon Acetylcholine Receptor Binding Regulation Of Biological Quality
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