DLG3 and GRIN2C

Number of citations of the paper that reports this interaction (PubMedID 11937501)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		DLG3	GRIN2C
Description		discs large MAGUK scaffold protein 3	glutamate ionotropic receptor NMDA type subunit 2C
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Organelle Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	Congenital heart disease (maternal effect) ( 28468790) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ
Entrez ID		1741	2905
HPRD ID		02177	00699
Ensembl ID		ENSG00000082458	ENSG00000161509
Uniprot IDs		Q59FY1 Q92796	A0A8D9PH81 H0Y2V8 O15398 Q14957 Q8IW23
PDB IDs		1UM7 2FE5 2I1N	8E92 8E93 8E94 8E97 8E98 8E99
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Postsynaptic Specialization Glutamatergic Synapse Cell Junction AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Binding Chemical Synaptic Transmission Receptor Clustering Receptor Localization To Synapse Trans-synaptic Signaling Synaptic Signaling Protein Localization To Synapse Protein Localization To Cell Junction Plasma Membrane P2Y1 Nucleotide Receptor Binding Postsynaptic Density Membrane Kinase Binding Basal Protein Localization Bicellular Tight Junction Cell-cell Signaling Signaling Cell Communication Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation ErbB-2 Class Receptor Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Adherens Junction AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Monocyte Chemotactic Protein-1 Production Cell Adhesion D1 Dopamine Receptor Binding Positive Regulation Of Interleukin-1 Alpha Production Cerebellar Mossy Fiber Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Postsynapse Hemidesmosome Basolateral Plasma Membrane Postsynaptic Density CD4 Receptor Binding Regulation Of Neutrophil Activation Juxtaparanode Region Of Axon
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