LPHN1 and SHANK1

Number of citations of the paper that reports this interaction (PMID 10964907)
14

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		LPHN1	SHANK1
Gene Name		latrophilin 1	SH3 and multiple ankyrin repeat domains 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse	Intracellular Cytoplasm Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Protein Binding Protein C-terminus Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules G-protein Coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation	Protein Complex Assembly Cytoskeletal Anchoring At Plasma Membrane Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Neuromuscular Process Controlling Balance Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778)
Protein-Protein Interactions		9 interactors: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2	17 interactors: ABCA1 ARHGEF7 BAI2 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 LPHN1 LPHN2 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1
Entrez ID		22859	50944
HPRD ID		14305	05413
Ensembl ID			ENSG00000161681
Uniprot IDs		O94910	H9KV90 Q9Y566
PDB IDs
Enriched GO Terms of Interacting Partners?		Vocalization Behavior Protein Localization To Synapse Synapse Organization Neuron Development Social Behavior Cell Development Receptor Clustering Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Nervous System Development Neuromuscular Process Controlling Balance Synapse Assembly Cell Morphogenesis Involved In Differentiation Receptor Localization To Synapse Dendrite Morphogenesis Neuron Projection Development Generation Of Neurons Cell Projection Morphogenesis Dendritic Spine Morphogenesis Cell Part Morphogenesis Neurogenesis Membrane Depolarization Neuromuscular Process Single-organism Behavior Learning Dendritic Spine Development Dendrite Development Regulation Of Signaling Cell Morphogenesis Dendritic Spine Organization Anatomical Structure Development Adult Behavior Reflex Cell Projection Organization Cell Differentiation Exploration Behavior Synaptic Transmission Behavior Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transport Developmental Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Signaling Cell Communication Positive Regulation Of Membrane Potential Learning Or Memory Regulation Of Membrane Potential System Development Cognition	Synaptic Transmission Neuron Projection Morphogenesis Cell Projection Organization Signaling Nervous System Development Cell Communication Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Response To External Stimulus Anatomical Structure Development Cell-cell Signaling Axon Development Regulation Of Cellular Component Organization System Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Cell Differentiation Signal Transduction Cell Morphogenesis Developmental Process Axon Guidance Neuron Differentiation Cell Morphogenesis Involved In Differentiation Response To Stimulus Multicellular Organismal Development Cell Development Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Chemotaxis Generation Of Neurons Cell Death Death Protein Localization To Synapse Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization G-protein Coupled Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Organic Substance Cellular Response To Organic Substance Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Response To Bacterium Neurotrophin TRK Receptor Signaling Pathway Response To Nutrient Neurotrophin Signaling Pathway
Tagcloud ?			akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?			akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?