ADGRL1 and SHANK1

Number of citations of the paper that reports this interaction (PubMedID 10964907)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ADGRL1	SHANK1
Description		adhesion G protein-coupled receptor L1	SH3 and multiple ankyrin repeat domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Neuron Projection Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		L1-L4 bone mineral density x serum urate levels interaction ( 34046847)	Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		10 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2 SHANK3	23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8
Entrez ID		22859	50944
HPRD ID		14305	05413
Ensembl ID		ENSG00000072071	ENSG00000161681
Uniprot IDs		O94910	H9KV90 Q9Y566
PDB IDs			6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Vocalization Behavior Synaptic Receptor Adaptor Activity Neuron Projection Social Behavior Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Dendritic Spine Learning Neuron Projection Organization Postsynapse Organization Receptor Clustering Neuromuscular Process Controlling Balance AMPA Glutamate Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Protein Localization To Synapse Postsynaptic Membrane Scaffold Protein Binding Neuron Spine Postsynaptic Density Learning Or Memory Protein Localization To Cell Junction Associative Learning Cognition Cell Projection Neurotransmitter-gated Ion Channel Clustering Neuromuscular Process SH3 Domain Binding Regulation Of Nervous System Process Postsynaptic Density Organization Positive Regulation Of Synaptic Transmission Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Synapse Postsynaptic Specialization Organization Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Adherens Junction Regulation Of Synaptic Plasticity Developmental Maturation Negative Regulation Of Actin Filament Bundle Assembly Nervous System Development Positive Regulation Of Dendritic Spine Development Ligand-gated Ion Channel Signaling Pathway	Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?