DLG3 and RPS8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DLG3	RPS8
Description		discs large MAGUK scaffold protein 3	ribosomal protein S8
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cytoplasmic Translation Translation Ribosomal Small Subunit Biogenesis
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	8 interacting genes: CALM1 DLG2 DLG3 DUX4 NDRG1 PDE4B SIRPA WEE2-AS1
Entrez ID		1741	6202
HPRD ID		02177	15969
Ensembl ID		ENSG00000082458	ENSG00000142937
Uniprot IDs		Q59FY1 Q92796	P62241 Q5JR94
PDB IDs		1UM7 2FE5 2I1N	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Calcium Channel Regulator Activity Adherens Junction Receptor Clustering Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Gamma-tubulin Binding Protein Localization To Synapse Response To Metal Ion Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Kinase Binding Response To Type II Interferon Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Voltage-gated Potassium Channel Complex Regulation Of Striated Muscle Contraction Protein Localization To Cell Junction Retrograde Axonal Protein Transport Neuromuscular Junction Negative Regulation Of Relaxation Of Cardiac Muscle Cellular Response To Interleukin-12 Kinase Binding Postsynaptic Density Membrane Cell-cell Adhesion Regulation Of Type II Interferon Production Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Myeloid Leukocyte Migration Transmembrane Transporter Binding Regulation Of Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Calcium Ion Transmembrane Transport Centrosome Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Relaxation Of Cardiac Muscle Nickel Cation Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Interleukin-12 Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Monocyte Extravasation Pre-mRNA 5'-splice Site Binding
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