DLG3 and DLGAP3

Number of citations of the paper that reports this interaction (PubMedID 9115257)
0

Data Source:
HPRD (two hybrid)

		DLG3	DLGAP3
Description		discs large MAGUK scaffold protein 3	DLG associated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Postsynaptic Density Membrane Neuromuscular Junction Synapse Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Amyloid-beta Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Signaling Modulation Of Chemical Synaptic Transmission Modification Of Postsynaptic Structure
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence ( 28440896)
Interacting Genes		51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN	15 interacting genes: DLG1 DLG2 DLG3 DLG4 DLGAP1 GOLGA2 KANK2 KRTAP1-3 KRTAP5-2 MAGEA6 MAGI2 PTK2 PTK2B SHANK2 SHANK3
Entrez ID		1741	58512
HPRD ID		02177	18935
Ensembl ID		ENSG00000082458	ENSG00000116544
Uniprot IDs		Q59FY1 Q92796	O95886
PDB IDs		1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane	Ionotropic Glutamate Receptor Binding Receptor Clustering Postsynaptic Density Neuron Projection Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Protein Localization To Cell Junction Vocalization Behavior Protein Kinase Binding Kinase Binding Postsynaptic Density Membrane Beta-1 Adrenergic Receptor Binding Positive Regulation Of Excitatory Postsynaptic Potential Localization Within Membrane Synaptic Receptor Adaptor Activity Chemical Synaptic Transmission Synapse Positive Regulation Of Synaptic Transmission Trans-synaptic Signaling AMPA Glutamate Receptor Clustering Synaptic Signaling Modulation Of Excitatory Postsynaptic Potential Phosphatase Binding Social Behavior Adherens Junction Neuron Spine Signal Complex Assembly Regulation Of Synaptic Plasticity GMP Kinase Activity GDP Metabolic Process Cell Projection Juxtaparanode Region Of Axon Modulation Of Chemical Synaptic Transmission Regulation Of Cell Morphogenesis Regulation Of Cellular Component Size Neurotransmitter-gated Ion Channel Clustering Regulation Of Cytoskeleton Organization Cellular Response To Potassium Ion Regulation Of Actin Filament Organization Glutamatergic Synapse Regulation Of Biological Quality Nervous System Development Dendritic Spine Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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