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LPHN1 and CACNA1A
Number of citations of the paper that reports this interaction (PMID
21078624
)
14
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
LPHN1
CACNA1A
Gene Name
latrophilin 1
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Cell Junction
Axon
Growth Cone
Presynaptic Membrane
Neuron Projection
Synapse
Nucleus
Cytoplasm
Plasma Membrane
Voltage-gated Calcium Channel Complex
Integral Component Of Membrane
Dendrite
Cell Projection
Neuronal Cell Body
Molecular Function
G-protein Coupled Receptor Activity
Protein Binding
Latrotoxin Receptor Activity
Carbohydrate Binding
Cell Adhesion Molecule Binding
Voltage-gated Calcium Channel Activity
Protein Binding
High Voltage-gated Calcium Channel Activity
Syntaxin Binding
Metal Ion Binding
Biological Process
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
G-protein Coupled Receptor Signaling Pathway
Calcium-mediated Signaling Using Intracellular Calcium Source
Positive Regulation Of Synapse Maturation
Sulfur Amino Acid Metabolic Process
Glucose Metabolic Process
Energy Reserve Metabolic Process
Positive Regulation Of Cytosolic Calcium Ion Concentration
Gamma-aminobutyric Acid Signaling Pathway
Synaptic Transmission
Neuromuscular Synaptic Transmission
Synapse Assembly
Adult Walking Behavior
Cell Death
Gamma-aminobutyric Acid Secretion
Regulation Of Acetylcholine Secretion, Neurotransmission
Cell Growth
Calcium Ion-dependent Exocytosis
Regulation Of Calcium Ion-dependent Exocytosis
Transmission Of Nerve Impulse
Spinal Cord Motor Neuron Differentiation
Cerebellum Maturation
Cerebellar Molecular Layer Development
Cerebellar Purkinje Cell Differentiation
Vestibular Nucleus Development
Cellular Chloride Ion Homeostasis
Negative Regulation Of Hormone Biosynthetic Process
Regulation Of Ion Transmembrane Transport
Synaptic Transmission, Glutamatergic
Neurotransmitter Metabolic Process
Hormone Metabolic Process
Receptor Clustering
Negative Regulation Of Neuron Apoptotic Process
Small Molecule Metabolic Process
Behavioral Response To Pain
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Dendrite Morphogenesis
Regulation Of Axonogenesis
Regulation Of Insulin Secretion
Musculoskeletal Movement, Spinal Reflex Action
Neuromuscular Process Controlling Balance
Membrane Depolarization
Rhythmic Synaptic Transmission
Calcium Ion Import
Calcium Ion Transmembrane Transport
Membrane Depolarization During Action Potential
Pathways
Integration of energy metabolism
Regulation of insulin secretion
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Transmission across Chemical Synapses
Drugs
Pregabalin
Verapamil
Loperamide
Bepridil
Diseases
GWAS
Mortality among heart failure patients (
20400778
)
Protein-Protein Interactions
9 interactors:
ANKS1A
APC
CACNA1A
DLG3
DLG4
PSMA3
ROS1
SHANK1
SHANK2
92 interactors:
ABCA2
ABI1
ACTN1
AGRN
ALDOA
AMIGO2
AP2M1
ARHGAP22
ASNA1
BTG3
BZRAP1
C1QTNF1
CABP1
CACNB1
CACNB4
CALM2
CALM3
CKAP5
CRIM1
CRMP1
CSNK2B
CYSRT1
DNAJB5
EFEMP1
EFEMP2
EHMT2
EIF3A
FBLN1
GNB1
GOLGA6L5P
GRN
HECW1
HHATL
HIVEP1
HSPG2
IP6K1
JAG2
KALRN
KHDRBS3
KIAA1191
LAMB1
LLGL1
LPHN1
LRP1
LTBP1
LTBP3
LTBP4
MANBAL
MATK
MATN2
MEGF6
MEGF8
MIA3
MOAP1
NDUFB8
NELFCD
NELL1
NELL2
NOTCH1
NOXA1
OLIG1
PCSK5
PCSK6
PMM1
PPIG
PPM1A
PPP1R12C
PTGDS
PUF60
RBM12B
RIMBP2
RPL31
RPS17
SCP2
SPRY1
SRRM4
SRSF1
SUMF2
SYT1
TAF15
TELO2
TSC22D1
TSPAN7
TUBB2B
UQCRC2
VARS
VPS52
VWF
WBP1
YLPM1
ZCCHC17
ZNF233
Entrez ID
22859
773
HPRD ID
14305
03004
Ensembl ID
ENSG00000141837
Uniprot IDs
O94910
B5TYJ1
O00555
Q9NS89
PDB IDs
3BXK
Enriched GO Terms of Interacting Partners
?
Vocalization Behavior
Protein Localization To Synapse
Synapse Organization
Neuron Development
Social Behavior
Cell Development
Receptor Clustering
Neuron Differentiation
Cell Morphogenesis Involved In Neuron Differentiation
Neuron Projection Morphogenesis
Nervous System Development
Neuromuscular Process Controlling Balance
Synapse Assembly
Cell Morphogenesis Involved In Differentiation
Receptor Localization To Synapse
Dendrite Morphogenesis
Neuron Projection Development
Generation Of Neurons
Cell Projection Morphogenesis
Dendritic Spine Morphogenesis
Cell Part Morphogenesis
Neurogenesis
Membrane Depolarization
Neuromuscular Process
Single-organism Behavior
Learning
Dendritic Spine Development
Dendrite Development
Regulation Of Signaling
Cell Morphogenesis
Dendritic Spine Organization
Anatomical Structure Development
Adult Behavior
Reflex
Cell Projection Organization
Cell Differentiation
Exploration Behavior
Synaptic Transmission
Behavior
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Ion Transport
Developmental Process
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Signaling
Cell Communication
Positive Regulation Of Membrane Potential
Learning Or Memory
Regulation Of Membrane Potential
System Development
Cognition
Secretion By Cell
Secretion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Voltage-gated Calcium Channel Activity
Detection Of Visible Light
Enzyme Linked Receptor Protein Signaling Pathway
Detection Of Light Stimulus
Multicellular Organismal Development
Phototransduction, Visible Light
Anatomical Structure Development
Cellular Localization
Axon Development
Developmental Process
Establishment Of Localization In Cell
Phototransduction
Regulation Of Cellular Process
System Development
Axonogenesis
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Calcium Ion Transmembrane Transporter Activity
Detection Of Abiotic Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Platelet Degranulation
Cell Morphogenesis Involved In Neuron Differentiation
Anatomical Structure Morphogenesis
Regulation Of Cation Channel Activity
Axon Guidance
Nervous System Development
Detection Of Calcium Ion
Regulation Of Intracellular Cholesterol Transport
Regulation Of Cell Communication By Electrical Coupling
Neuron Projection Morphogenesis
Exocytosis
Neuron Projection Development
Cellular Response To Growth Factor Stimulus
Neuron Differentiation
Inositol Phosphate Metabolic Process
Cell Projection Morphogenesis
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Cell Morphogenesis Involved In Differentiation
Cell Part Morphogenesis
Response To Growth Factor
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Cation Channel Activity
Platelet Activation
Cell-cell Signaling
Nerve Growth Factor Processing
Pathogenesis
Neurotrophin TRK Receptor Signaling Pathway
Tagcloud
?
acetazolamide
ataxia
attacks
autosomal
causative
causing
coincidence
confutes
defect
dysarthria
dystonia
ea
ea2
encodes
episodes
episodic
gait
gated
heterogeneous
inherited
migraine
mim
nonsense
oculomotor
paroxysmal
q
varied
voltage
Tagcloud (Difference)
?
acetazolamide
ataxia
attacks
autosomal
causative
causing
coincidence
confutes
defect
dysarthria
dystonia
ea
ea2
encodes
episodes
episodic
gait
gated
heterogeneous
inherited
migraine
mim
nonsense
oculomotor
paroxysmal
q
varied
voltage
Tagcloud (Intersection)
?