DLG3 and NLGN3

Number of citations of the paper that reports this interaction (PMID 9278515)
105

Data Source:
HPRD (two hybrid)

		DLG3	NLGN3
Gene Name		discs, large homolog 3 (Drosophila)	neuroligin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding	Receptor Activity Protein Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Synapse Assembly Learning Metabolic Process Visual Learning Adult Behavior Social Behavior Axon Extension Oligodendrocyte Differentiation Regulation Of Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1	8 interactors: DLG2 DLG3 DLG4 MEOX2 NRXN1 NRXN2 NRXN3 PRDX2
Entrez ID		1741	54413
HPRD ID		02177	02275
Ensembl ID		ENSG00000082458	ENSG00000196338
Uniprot IDs		Q59FY1 Q92796	D3DVV1 Q4G160 Q9NZ94
PDB IDs		1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization	Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synapse Assembly Synaptic Transmission Neuron Cell-cell Adhesion Protein Localization To Membrane Postsynaptic Membrane Organization Learning Cell-cell Signaling Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Vocal Learning Regulation Of Grooming Behavior Learning Or Memory Postsynaptic Membrane Assembly Cognition Postsynaptic Density Protein 95 Clustering Membrane Organization Auditory Behavior Neurotransmitter Secretion Axon Guidance Positive Regulation Of Synapse Maturation Single-organism Behavior Regulation Of Neurotransmitter Levels Regulation Of Synapse Maturation Secretion By Cell Neurological System Process Mechanosensory Behavior Axonogenesis Response To Auditory Stimulus Neurotransmitter Transport Adult Behavior Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Nervous System Development Membrane Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Cellular Localization Chemotaxis Cellular Protein Localization Membrane Biogenesis Secretion Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity
Tagcloud ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube
Tagcloud (Difference) ?		17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity	88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube
Tagcloud (Intersection) ?