ADGRL1 and SHANK2

Number of citations of the paper that reports this interaction (PubMedID 10964907)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ADGRL1	SHANK2
Description		adhesion G protein-coupled receptor L1	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Neuron Projection Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		L1-L4 bone mineral density x serum urate levels interaction ( 34046847)	Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		10 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2 SHANK3	21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		22859	22941
HPRD ID		14305	04479
Ensembl ID		ENSG00000072071	ENSG00000162105
Uniprot IDs		O94910	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs			8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Vocalization Behavior Synaptic Receptor Adaptor Activity Neuron Projection Social Behavior Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Dendritic Spine Learning Neuron Projection Organization Postsynapse Organization Receptor Clustering Neuromuscular Process Controlling Balance AMPA Glutamate Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Protein Localization To Synapse Postsynaptic Membrane Scaffold Protein Binding Neuron Spine Postsynaptic Density Learning Or Memory Protein Localization To Cell Junction Associative Learning Cognition Cell Projection Neurotransmitter-gated Ion Channel Clustering Neuromuscular Process SH3 Domain Binding Regulation Of Nervous System Process Postsynaptic Density Organization Positive Regulation Of Synaptic Transmission Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Synapse Postsynaptic Specialization Organization Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Adherens Junction Regulation Of Synaptic Plasticity Developmental Maturation Negative Regulation Of Actin Filament Bundle Assembly Nervous System Development Positive Regulation Of Dendritic Spine Development Ligand-gated Ion Channel Signaling Pathway	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse
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