CTSG and ERBIN

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		CTSG	ERBIN
Description		cathepsin G	erbb2 interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection	Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		1511	55914
HPRD ID		00289	06090
Ensembl ID		ENSG00000100448	ENSG00000112851
Uniprot IDs		P08311	A0A8V8TML4 A0A8V8TPC7 Q96RT1
PDB IDs		1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK	1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation
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