CTSG and VCAM1

Number of citations of the paper that reports this interaction (PubMedID 11520773)
0

Data Source:
HPRD (in vitro)

		CTSG	VCAM1
Description		cathepsin G	vascular cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome	Podosome Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding	Integrin Binding Primary Methylamine Oxidase Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation	Response To Hypoxia Chronic Inflammatory Response Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Membrane To Membrane Docking B Cell Differentiation Response To Lipopolysaccharide Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Leukocyte Tethering Or Rolling Cell Chemotaxis Innervation Cardiac Neuron Differentiation Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Cellular Response To Amyloid-beta
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Ethanol Carvedilol Succinobucol Clove oil
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088 24076602 31604244) Neutrophil percentage of white cells ( 32888494) Sjögren's syndrome ( 24097067)
Interacting Genes		30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	13 interacting genes: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN TRIM54 TRIM65 USP2
Entrez ID		1511	7412
HPRD ID		00289	01888
Ensembl ID		ENSG00000100448	ENSG00000162692
Uniprot IDs		P08311	P19320
PDB IDs		1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK	1IJ9 1VCA 1VSC
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport	Immune System Process Immune Response Leukocyte Cell-cell Adhesion Leukocyte Migration Cell Adhesion Molecule Binding Integrin Complex Killing Of Cells Of Another Organism Inflammatory Response Heterotypic Cell-cell Adhesion Cell Migration Defense Response Membrane To Membrane Docking Cell Motility Response To Other Organism Cell Killing Defense Response To Symbiont Positive Regulation Of Early Endosome To Late Endosome Transport Defense Response To Other Organism Positive Regulation Of Protein Localization To Early Endosome Neutrophil-mediated Killing Of Bacterium Filopodium Cell-cell Adhesion Positive Regulation Of Protein Localization To Endosome Response To External Biotic Stimulus Uropod Integrin-mediated Signaling Pathway Cell-matrix Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Mononuclear Cell Migration Regulation Of Early Endosome To Late Endosome Transport Extracellular Space Leukocyte Tethering Or Rolling Neutrophil Mediated Immunity Cell Surface Establishment Of Apical/basal Cell Polarity Leukocyte Adhesion To Vascular Endothelial Cell Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Adhesion Mediated By Integrin Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell-substrate Adhesion Antimicrobial Humoral Response Killing By Host Of Symbiont Cells Cytokine-mediated Signaling Pathway Focal Adhesion T Cell Migration Biological Process Involved In Interaction With Symbiont
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