CTSG and CXCL12

Number of citations of the paper that reports this interaction (PMID 11241273)
29

Data Source:
HPRD (in vitro, in vivo)

		CTSG	CXCL12
Gene Name		cathepsin G	chemokine (C-X-C motif) ligand 12
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity	Receptor Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium	Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Cell Adhesion Signal Transduction G-protein Coupled Receptor Signaling Pathway Germ Cell Development Blood Circulation Motor Neuron Axon Guidance Regulation Of Actin Polymerization Or Depolymerization Adult Locomotory Behavior Germ Cell Migration Response To Radiation Response To Heat Response To Mechanical Stimulus Response To Virus Telencephalon Cell Migration Organ Regeneration Positive Regulation Of Dopamine Secretion T Cell Proliferation Response To Peptide Hormone Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Induction Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Myoblast Fusion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signaling by ERBB4 GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Nuclear signaling by ERBB4 Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Tinzaparin
Diseases
GWAS			Coronary heart disease ( 17634449 21378990) Myocardial infarction (early onset) ( 19198609) Schizophrenia ( 23212062)
Protein-Protein Interactions		28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	10 interactors: CD4 CTSG CXCR4 DAZAP2 DPP4 ELANE FN1 MMP2 PF4 VCAN
Entrez ID		1511	6387
HPRD ID		00289	02904
Ensembl ID		ENSG00000100448	ENSG00000107562
Uniprot IDs		P08311	H7BYN8 P48061
PDB IDs		1AU8 1CGH 1KYN 1T32	1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2NWG 2SDF 3GV3 3HP3 4LMQ
Enriched GO Terms of Interacting Partners?		Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility	Locomotion Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Movement Of Cell Or Subcellular Component Cell Migration Positive Regulation Of Immune System Process Cell Motility Leukocyte Migration Response To Stress Immune System Process Regulation Of Immune System Process Cell Activation Defense Response Response To Other Organism Killing By Host Of Symbiont Cells Response To Biotic Stimulus Inflammatory Response Response To External Stimulus Regulation Of Chemotaxis Response To Bacterium Neutrophil Mediated Immunity Cell Adhesion Killing Of Cells Of Other Organism Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Positive Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Endodermal Cell Differentiation Response To Fungus Entry Into Host Cell T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Intracellular Signal Transduction Response To Hypoxia Response To Lipopolysaccharide Leukocyte Cell-cell Adhesion Endoderm Formation Regulation Of Immune Response Cardiovascular System Development Homotypic Cell-cell Adhesion Angiogenesis Response To Molecule Of Bacterial Origin Chemokine-mediated Signaling Pathway Collagen Catabolic Process
Tagcloud ?		aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram	adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Difference) ?		aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram	adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Intersection) ?