CTSG and SERPINB4

Number of citations of the paper that reports this interaction (PubMedID 12949073)
0

Data Source:
BioGRID (pull down)

		CTSG	SERPINB4
Description		cathepsin G	serpin family B member 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity
	Biological Process	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation	Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Protection From Natural Killer Cell Mediated Cytotoxicity
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	2 interacting genes: CTSG CTSS
Entrez ID		1511	6318
HPRD ID		00289	02746
Ensembl ID		ENSG00000100448	ENSG00000206073
Uniprot IDs		P08311	P48594 Q9BYF7
PDB IDs		1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport	Extracellular Matrix Disassembly Biofilm Matrix Disassembly Serine-type Endopeptidase Activity Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Basement Membrane Disassembly Extracellular Matrix Endolysosome Lumen Peptidase Activity Lysosome Positive Regulation Of Immune Response Neutrophil-mediated Killing Of Bacterium Angiotensin Maturation Caspase Binding Positive Regulation Of Platelet Aggregation Cellular Response To Thyroid Hormone Stimulus Proteoglycan Binding Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neutrophil Mediated Immunity Monocyte Chemotaxis Regulation Of Antigen Processing And Presentation Laminin Binding Response To Thyroid Hormone Positive Regulation Of Cation Channel Activity Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Platelet Aggregation Killing By Host Of Symbiont Cells Neutrophil Activation Response To Acidic PH Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding Basement Membrane Organization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Peptide Hormone Processing Biological Process Involved In Interaction With Symbiont Proteolysis Collagen Catabolic Process Positive Regulation Of Ion Transmembrane Transporter Activity Response To PH Positive Regulation Of Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Immune Response Signaling Receptor Ligand Precursor Processing Antigen Processing And Presentation Of Exogenous Antigen
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