CTSG and SERPIND1

Number of citations of the paper that reports this interaction (PMID 2318847)
8

Data Source:
HPRD (in vitro)

		CTSG	SERPIND1
Gene Name		cathepsin G	serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding
	Biological Process	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix	Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Ardeparin Alpha-D-Mannose Sulodexide
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	4 interactors: APP CTSG ELANE F2
Entrez ID		1511	3053
HPRD ID		00289	00795
Ensembl ID		ENSG00000100448	ENSG00000099937
Uniprot IDs		P08311	P05546 Q8IVC0
PDB IDs		1AU8 1CGH 1KYN 1T32	1JMJ 1JMO
Enriched GO Terms of Interacting Partners?		Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility	Killing By Host Of Symbiont Cells Regulation Of Growth Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Defense Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Extracellular Matrix Organization Extracellular Structure Organization Response To Fungus Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Acute Inflammatory Response Immune System Process Regulation Of Protein Metabolic Process Extracellular Matrix Disassembly Cellular Homeostasis Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Negative Regulation Of Protein Metabolic Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Synaptic Growth At Neuromuscular Junction Regulation Of Protein Phosphorylation Defense Response To Bacterium Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Leukocyte Migration Positive Regulation Of Protein Metabolic Process Locomotion Negative Regulation Of Growth Immune Response Regulation Of Phosphorylation Leukocyte Mediated Immunity Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Neurogenesis
Tagcloud ?		aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Difference) ?		aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Intersection) ?