CTSG and CAMP

Number of citations of the paper that reports this interaction (PubMedID 11389039)
0

Data Source:
HPRD (in vitro, in vivo)

		CTSG	CAMP
Description		cathepsin G	cathelicidin antimicrobial peptide
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Vesicle Specific Granule Lumen Specific Granule Cell Projection Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding	Lipopolysaccharide Binding Protein Binding
	Biological Process	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation	Response To Yeast Innate Immune Response In Mucosa Immune System Process Prostaglandin Production Involved In Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Antimicrobial Humoral Response Defense Response Positive Regulation Of Cell Population Proliferation Response To Glucose Leukotriene Biosynthetic Process Antibacterial Humoral Response Antifungal Humoral Response Cytolysis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Modulation Of Process Of Another Organism Neutrophil Activation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dentinogenesis Cellular Response To Butyrate Amyloid Fibril Formation
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection	Neutrophil degranulation Antimicrobial peptides
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Selenocysteine
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	9 interacting genes: ACE2 CTSG ELANE F10 F2 FPR2 LBP MAPK8 PRTN3
Entrez ID		1511	820
HPRD ID		00289	02722
Ensembl ID		ENSG00000100448	ENSG00000164047
Uniprot IDs		P08311	A0A384NPR0 J3KNB4 P49913
PDB IDs		1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK	2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX 6S6M 7NPQ 7PDC 7SAY 8DEW
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport	Response To External Biotic Stimulus Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Serine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Peptidase Activity Neutrophil Mediated Immunity Killing By Host Of Symbiont Cells Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Response To Bacterium Cellular Response To Lipopolysaccharide Regulation Of Inflammatory Response Response To Lipid Neutrophil-mediated Killing Of Gram-negative Bacterium Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Cell Migration Extracellular Space Acute Inflammatory Response Regulation Of Leukocyte Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Migration Regulation Of Immune Response Regulation Of Immune System Process Hydrolase Activity Positive Regulation Of Signal Transduction Leukocyte Mediated Cytotoxicity Cell Motility Azurophil Granule Lumen Endopeptidase Activity Angiotensin Maturation Positive Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of Catalytic Activity Proteolysis Chemotaxis Immune System Process Locomotion Defense Response To Symbiont Regulation Of Intracellular Signal Transduction Killing Of Cells Of Another Organism Defense Response To Other Organism Leukocyte Migration Involved In Inflammatory Response Myeloid Leukocyte Migration
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