CTSG and F5

Number of citations of the paper that reports this interaction (PubMedID 9718313)
0

Data Source:
HPRD (in vitro)

		CTSG	F5
Description		cathepsin G	coagulation factor V
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding	Copper Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation	Blood Coagulation Hemostasis Blood Circulation Response To Vitamin K
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases			Factor V deficiency; Owren disease Inherited thrombophilia
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)	Activated partial thromboplastin time ( 22703881 29403010) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Iron status biomarkers (ferritin levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Ischemic stroke ( 26732560) Macrovascular complications in type 2 diabetes ( 33430853) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 31798171 25631615) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 32232851 33592630 31676865 31420334 28373160 25772935 23650146 22672568 21980494) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2
Entrez ID		1511	2153
HPRD ID		00289	01964
Ensembl ID		ENSG00000100448	ENSG00000198734
Uniprot IDs		P08311	P12259
PDB IDs		1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK	1CZS 1CZT 1CZV 3P6Z 3P70 3S9C 7KVE 7KVF 7KXY 7TPP 8FDG 8TN9 9CTH
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport	Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Neutrophil-mediated Killing Of Bacterium Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Regulation Of Platelet Activation Acute Inflammatory Response Negative Regulation Of Wound Healing Leukocyte Mediated Cytotoxicity Neutrophil Mediated Immunity Golgi Lumen Regulation Of Body Fluid Levels Killing By Host Of Symbiont Cells Extracellular Region Extracellular Space Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Wound Healing External Side Of Plasma Membrane Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Immune Effector Process Regulation Of Response To Wounding Negative Regulation Of Coagulation Extracellular Matrix Cell Killing Peptidase Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Defense Response Positive Regulation Of Phagocytosis Azurophil Granule Lumen Positive Regulation Of Platelet Aggregation Endopeptidase Activity IgG Binding Regulation Of Multicellular Organismal Process Endoplasmic Reticulum Lumen Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Response To Stress Response To Other Organism Positive Regulation Of Homotypic Cell-cell Adhesion Fibrinolysis Blood Microparticle Killing Of Cells Of Another Organism Negative Regulation Of Multicellular Organismal Process
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