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TRIM27 and UBE2I
Number of citations of the paper that reports this interaction (PubMedID
20972456
)
43
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
TRIM27
UBE2I
Description
tripartite motif containing 27
ubiquitin conjugating enzyme E2 I
Image
No pdb structure
GO Annotations
Cellular Component
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Cytosol
PML Body
Retromer Complex
Nuclear Membrane
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Body
PML Body
Perinuclear Region Of Cytoplasm
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
SUMO Ligase Complex
Transferase Complex
Molecular Function
Nucleic Acid Binding
DNA Binding
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Phosphatidylinositol 3-kinase Inhibitor Activity
Nucleotide Binding
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
Transferase Activity
SUMO Transferase Activity
Enzyme Binding
HLH Domain Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Spermatogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Sumoylation
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Viral Transcription
Arp2/3 Complex-mediated Actin Nucleation
Retrograde Transport, Endosome To Golgi
Suppression Of Viral Release By Host
Innate Immune Response
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Actin Nucleation
Protein K63-linked Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Chromosome Segregation
Mitotic Nuclear Membrane Reassembly
Protein Sumoylation
Positive Regulation Of Cell Migration
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA-templated Transcription
Modulation Of Chemical Synaptic Transmission
Nuclear Export
Cell Division
Pathways
SUMOylation of ubiquitinylation proteins
Regulation of PTEN stability and activity
Suppression of apoptosis
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SUMOylation of nuclear envelope proteins
PKR-mediated signaling
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Asthma (
31619474
32296059
29273806
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Childhood and early adolescence aggressive behavior (
26087016
)
Daytime sleep phenotypes (
27126917
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Experiencing mood swings (
29500382
)
Feeling miserable (
29500382
)
Fish- and plant-related diet (
32066663
)
General risk tolerance (MTAG) (
30643258
)
Hand grip strength (
29691431
)
Heel bone mineral density (
30598549
)
Hemoglobin levels (
32327693
)
Liver iron content (
34128465
)
Lung cancer in ever smokers (
28604730
)
Neurociticism (
29500382
)
Platelet aggregation (
20526338
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) (
26651848
)
Schizophrenia (
30285260
)
Social communication problems (
24047820
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Appendicular lean mass (
33097823
)
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Interacting Genes
353 interacting genes:
ABCA1
ABCF3
ABHD17A
ACSF3
AEN
AIRIM
AMMECR1
AMOTL2
AP1M1
ARHGEF3
ARHGEF5
ARID5A
ARIH2
ARMC7
ARNT2
ARPIN
ATOSA
ATOSB
ATPAF2
ATXN7
AXIN1
BABAM1
BAG1
BAG3
BAG5
BEGAIN
BEX2
BMI1
BMP7
BYSL
CAPN7
CARD10
CATSPER1
CBX8
CCDC102B
CCDC185
CCDC187
CCDC198
CCDC87
CCDC92
CCHCR1
CDC20B
CDC23
CDC7
CDK18
CDKL3
CFAP206
CFTR
CHCHD3
CHD4
CHUK
CIMIP4
CKS1B
CLK2
CNNM3
COX5B
CPNE2
CPNE7
CREB5
CSRP2
CWF19L2
DBF4B
DCX
DDX6
DGCR6
DMRT3
DNMT1
DTNB
DTNBP1
EHHADH
EID1
EIF3D
EIF3E
EIF4A3
EIF4E
EIF4E2
ENKD1
EPC1
ERCC3
EXOC8
FAM110A
FAM161A
FAM193B
FAM83A
FAM90A1
FANCM
FARS2
FASTKD5
FBF1
FBXL19
FBXW5
FHL3
FNDC11
FOXB1
FOXC2
FXYD6
GADD45GIP1
GAS2L2
GATAD2B
GCC2-AS1
GEM
GFAP
GFI1B
GFM2
GLYCTK
GNE
GNPDA2
GPANK1
GPKOW
GRB14
GRB2
GSE1
GTF2F1
HAPLN2
HAUS1
HCK
HDAC1
HDAC4
HGS
HIP1R
HNRNPLL
HOXB5
HOXB9
HOXC8
HR
HYCC1
HYCC2
IGFN1
IKBKB
IKBKE
IL16
ILF2
ILK
INO80B
INPP5J
IP6K3
IQCE
IQCN
IQUB
JOSD1
KANSL1
KAT14
KAT5
KCTD15
KCTD9
KIF1A
KIF9
KIFC3
KRT3
KRT75
KRT76
LAGE3
LASP1
LENG1
LGALS14
LINC00526
LINGO1
LMNB2
LMO1
LMO4
LNX1
LONRF1
MAD2L2
MAGEA11
MAGED4B
MAGEF1
MAGOHB
MAPKBP1
MAT2B
MBD4
MCM7
MCOLN1
MDM2
MED21
MEMO1
MIA3
MID2
MOS
MRPL40
MSRB1
MTMR6
MVP
MYO15B
NCK2
NCOA1
NDE1
NEBL
NEDD9
NEIL2
NEK6
NELFE
NIF3L1
NME7
NOTCH2NLA
NR1D2
NTAQ1
NUDT21
OAS1
OGT
OTUB2
P2RX7
PIAS1
PIAS2
PIAS3
PIAS4
PIBF1
PIMREG
PIN1
PLEKHN1
PML
POLE2
POLR1C
POLR3C
POM121
PPID
PPL
PPP1R18
PRAM1
PRKAA1
PRPF18
PRPF31
PRR35
PSMA1
PSMB1
PSMB3
PTPMT1
PTPN23
PUS7L
QARS1
RAB29
RAMAC
RB1
RBM23
RBM41
RBX1
RCOR3
REL
RHPN1
RIBC1
RIN1
RNF213
RNF25
RNF6
RSPH14
RXRB
SCNM1
SDCBP
SH2D4A
SHANK3
SIAH1
SIRPA
SLC15A3
SMARCB1
SMARCD1
SMG9
SNRPA
SNRPB2
SORBS3
SPATA2
SPATC1L
SQSTM1
SRSF2
STAMBPL1
STK16
STK25
STK26
SYNGAP1
SYT17
SYT6
TACO1
TBC1D22B
TCEA2
TCEANC
TCHP
THOC1
TLE5
TMSB4X
TMSB4XP6
TNS4
TPM3
TPRKB
TRAF4
TRAF5
TRIM11
TRIM21
TRIM23
TRIM29
TRIM31
TRIM32
TRIM42
TRIM43
TRIM50
TRIM55
TRIM9
TSGA10IP
TSHZ3
TTLL10
TUBGCP4
TUFT1
TXNDC9
UBASH3A
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2J1
UBE2K
UBE2L6
UBE2N
UBE2O
UBE2T
UBE2U
UBE2W
UBE2Z
UBL5
UCHL3
UCHL5
UHRF2
USE1
USP2
UTP14C
UTP23
VEZF1
VPS25
VPS28
VPS9D1
WT1-AS
XPA
YJU2
ZBTB16
ZC2HC1C
ZFC3H1
ZFHX3
ZFYVE21
ZGPAT
ZMYND19
ZNF250
ZNF384
ZNF414
ZNF417
ZNF446
ZNF572
ZNF580
ZNF581
ZNF587
ZNF688
ZNF79
486 interacting genes:
-
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARK2N
ARL13B
ARL6IP1
ARNT
ARRB2
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMAL1
BMI1
BTBD3
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDR2L
CEBPA
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
EIF5A
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4C16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAP3K5
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MBD4
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MORC3
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFE2
NFKBIA
NHP2
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NRIP1
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PCNA
PDLIM7
PDPK1
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PLK1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBBP8
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOB
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
ROCK2
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STIP1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
USP36
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
YY1
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
Entrez ID
5987
7329
HPRD ID
15996
09045
Ensembl ID
ENSG00000204713
ENSG00000103275
Uniprot IDs
A0A1U9X8R9
P14373
A8K503
P63279
Q7KZS0
PDB IDs
1A3S
1KPS
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
8ODR
9B62
Enriched GO Terms of Interacting Partners
?
Protein Binding
Ubiquitin Conjugating Enzyme Activity
Nucleus
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Protein Ubiquitination
Protein Polyubiquitination
Nucleoplasm
Protein Modification Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein K48-linked Ubiquitination
SUMO Transferase Activity
Macromolecule Catabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein K63-linked Ubiquitination
Regulation Of RNA Metabolic Process
Protein Metabolic Process
Ubiquitin Protein Ligase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cytoplasm
Ubiquitin Protein Ligase Binding
Protein K6-linked Ubiquitination
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Protein Monoubiquitination
Regulation Of Primary Metabolic Process
Proteolysis
Zinc Ion Binding
PML Body
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cytosol
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Sumoylation
Transferase Activity
Protein K11-linked Ubiquitination
ATP Binding
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Nucleus
Nucleoplasm
Identical Protein Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Macromolecule Metabolic Process
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
PML Body
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleic Acid Metabolic Process
Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Cellular Response To Stress
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-templated Transcription
Nucleobase-containing Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Transcription Cis-regulatory Region Binding
Zinc Ion Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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