TRIM27 and CDC23

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TRIM27	CDC23
Gene Name		tripartite motif containing 27	cell division cycle 23
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Integral Component Of Plasma Membrane Membrane PML Body Retromer Complex Nuclear Membrane	Intracellular Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Nucleic Acid Binding DNA Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adaptive Immune Response Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Spermatogenesis Cell Proliferation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Trimerization Protein K63-linked Ubiquitination Interferon-gamma Secretion Negative Regulation Of Calcium Ion Import Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Viral Release From Host Cell	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Platelet aggregation ( 20526338)
Protein-Protein Interactions		254 interactors: ABCA1 ABCF3 AEN AES AMOTL2 ARHGEF3 ARHGEF5 ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 BABAM1 BAG1 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C14orf105 C20orf195 CCDC102B CCDC87 CCDC92 CCDC94 CCHCR1 CDC20B CDC23 CDK18 CDKL3 CHCHD3 CHD4 CHUK CKS1B CLK2 CPNE2 CSRP2 CSRP2BP CWF19L2 DCX DDX6 DGCR6 DMRT3 DNMT1 DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4E EIF4E2 EPC1 FAM103A1 FAM110A FAM126B FAM193B FAM214A FAM214B FAM64A FAM83A FANCM FARS2 FBF1 FBXL19 FBXW5 FHL3 FLJ38668 FOXB1 FOXC2 FXYD6 GATAD2B GEM GFAP GFI1B GFM2 GLYCTK GNPDA2 GPANK1 GRB2 GTF2F1 HAUS1 HDAC1 HR IKBKB IKBKE ILK INPP5J IQCE IQUB JOSD1 KANSL1 KAT5 KCTD15 KCTD9 KIAA1683 KIF1A KIF9 KIFC3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMO1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MTMR6 MVP NCK2 NDE1 NDEL1 NEBL NEDD9 NEIL2 NEK6 NELFE NME7 NOTCH2NL NR1D2 NUDT21 OAS1 OTUB2 PIAS1 PIAS2 PIAS3 PIAS4 PLEKHN1 PML POLE2 POLR1C POLR3C PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF31 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L RAB29 RB1 RBM23 RBM41 RBX1 RCOR3 RHPN1 RIBC1 RNF213 RNF25 SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 TBC1D22B TBK1 TCEA2 TCHP TEAD4 TMSB4X TMSB4XP6 TP53 TPM3 TPRKB TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UCHL3 UCHL5 UHRF2 USE1 USP2 USP7 UTP23 VPS25 VPS28 WDYHV1 WT1-AS XPA ZBTB16 ZC2HC1C ZFC3H1 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF417 ZNF446 ZNF572 ZNF581 ZNF79	44 interactors: ANAPC10 ANAPC13 APOL1 ATRIP BCAS3 BYSL CCDC24 CCDC36 CDC16 CDH1 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SOX5 SPERT SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S
Entrez ID		5987	8697
HPRD ID		15996	07221
Ensembl ID		ENSG00000204713	ENSG00000094880
Uniprot IDs		P14373	Q9UJX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Cellular Metabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Biosynthetic Process Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gene Expression Cell Cycle RNA Metabolic Process Cellular Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Catabolic Process Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Metabolic Process	Protein K11-linked Ubiquitination Cell Cycle Regulation Of Organelle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Protein Polyubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Division Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Cell Cycle Checkpoint Protein Modification By Small Protein Conjugation Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		bolstered compacta da decreases deficiency degeneration dopamine dopaminergic dramatically exists linkage movement mptp neurodegenerative neuron neurotoxin nigra obvious parkinson pars pc12 pd promote protects rnai shared snpc substantia upregulated	34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Difference) ?		bolstered compacta da decreases deficiency degeneration dopamine dopaminergic dramatically exists linkage movement mptp neurodegenerative neuron neurotoxin nigra obvious parkinson pars pc12 pd promote protects rnai shared snpc substantia upregulated	34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Intersection) ?