TRIM27 and UBE2W

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		TRIM27	UBE2W
Gene Name		tripartite motif containing 27	ubiquitin-conjugating enzyme E2W (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Integral Component Of Plasma Membrane Membrane PML Body Retromer Complex Nuclear Membrane	Nucleus Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adaptive Immune Response Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Spermatogenesis Cell Proliferation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Trimerization Protein K63-linked Ubiquitination Interferon-gamma Secretion Negative Regulation Of Calcium Ion Import Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Viral Release From Host Cell	DNA Repair Protein Monoubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Platelet aggregation ( 20526338)
Protein-Protein Interactions		254 interactors: ABCA1 ABCF3 AEN AES AMOTL2 ARHGEF3 ARHGEF5 ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 BABAM1 BAG1 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C14orf105 C20orf195 CCDC102B CCDC87 CCDC92 CCDC94 CCHCR1 CDC20B CDC23 CDK18 CDKL3 CHCHD3 CHD4 CHUK CKS1B CLK2 CPNE2 CSRP2 CSRP2BP CWF19L2 DCX DDX6 DGCR6 DMRT3 DNMT1 DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4E EIF4E2 EPC1 FAM103A1 FAM110A FAM126B FAM193B FAM214A FAM214B FAM64A FAM83A FANCM FARS2 FBF1 FBXL19 FBXW5 FHL3 FLJ38668 FOXB1 FOXC2 FXYD6 GATAD2B GEM GFAP GFI1B GFM2 GLYCTK GNPDA2 GPANK1 GRB2 GTF2F1 HAUS1 HDAC1 HR IKBKB IKBKE ILK INPP5J IQCE IQUB JOSD1 KANSL1 KAT5 KCTD15 KCTD9 KIAA1683 KIF1A KIF9 KIFC3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMO1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MTMR6 MVP NCK2 NDE1 NDEL1 NEBL NEDD9 NEIL2 NEK6 NELFE NME7 NOTCH2NL NR1D2 NUDT21 OAS1 OTUB2 PIAS1 PIAS2 PIAS3 PIAS4 PLEKHN1 PML POLE2 POLR1C POLR3C PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF31 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L RAB29 RB1 RBM23 RBM41 RBX1 RCOR3 RHPN1 RIBC1 RNF213 RNF25 SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 TBC1D22B TBK1 TCEA2 TCHP TEAD4 TMSB4X TMSB4XP6 TP53 TPM3 TPRKB TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UCHL3 UCHL5 UHRF2 USE1 USP2 USP7 UTP23 VPS25 VPS28 WDYHV1 WT1-AS XPA ZBTB16 ZC2HC1C ZFC3H1 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF417 ZNF446 ZNF572 ZNF581 ZNF79	69 interactors: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MARCH3 MARCH5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF185 RNF2 RNF26 RNF4 RNF5 RNF8 ROPN1 STUB1 TOPORS TRIM17 TRIM2 TRIM27 TRIM31 TRIM35 TRIM39 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		5987	55284
HPRD ID		15996	07724
Ensembl ID		ENSG00000204713	ENSG00000104343
Uniprot IDs		P14373	Q96B02 Q96FI0
PDB IDs			2A7L
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Cellular Metabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Biosynthetic Process Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gene Expression Cell Cycle RNA Metabolic Process Cellular Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Catabolic Process Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Metabolic Process Cellular Response To Stress Catabolic Process Protein Monoubiquitination Response To Stress Cellular Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Release From Host Cell Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell DNA Repair Negative Regulation Of Viral Transcription Proteolysis Apoptotic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Viral Transcription Programmed Cell Death Negative Regulation Of Viral Process Regulation Of Viral Process Cell Death Death Positive Regulation Of Organelle Organization Genetic Imprinting Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Histone Methylation Histone Ubiquitination Cellular Response To Stimulus
Tagcloud ?		bolstered compacta da decreases deficiency degeneration dopamine dopaminergic dramatically exists linkage movement mptp neurodegenerative neuron neurotoxin nigra obvious parkinson pars pc12 pd promote protects rnai shared snpc substantia upregulated	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Difference) ?		bolstered compacta da decreases deficiency degeneration dopamine dopaminergic dramatically exists movement mptp neurodegenerative neuron neurotoxin nigra obvious parkinson pars pc12 pd promote protects rnai shared snpc substantia upregulated	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Intersection) ?		linkage