VPS41 and HOOK1

Number of citations of the paper that reports this interaction (PubMedID 18799622)
36

Data Source:
HPRD (in vivo)

		VPS41	HOOK1
Description		VPS41 subunit of HOPS complex	hook microtubule tethering protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Cytosol Endosome Membrane Microtubule Cytoskeleton Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Clathrin Complex Lysosomal HOPS Complex	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Protein Targeting To Vacuole Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Protein Transport Vesicle-mediated Transport Macroautophagy Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Golgi Vesicle Transport Late Endosome To Lysosome Transport	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Breast cancer and/or colorectal cancer ( 29698419) Cognitive performance ( 19734545)	Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B	46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80
Entrez ID		27072	51361
HPRD ID		10402	07428
Ensembl ID		ENSG00000006715	ENSG00000134709
Uniprot IDs		P49754	Q9UJC3
PDB IDs
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport Vacuolar Transport Early Endosome To Late Endosome Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Vesicle Organization HOPS Complex Endosomal Transport Vesicle-mediated Transport Intracellular Transport Endosome Organization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Lysosome Organization Vacuole Organization Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Protein Localization Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Presynaptic Endosome Cytoplasmic Microtubule Organization Microtubule-based Process Axo-dendritic Transport Protein Localization To Vacuole Phagosome-lysosome Fusion Neurotransmitter Receptor Transport Synaptic Vesicle Recycling Protein Localization To Organelle Ubiquitin-like Protein Transferase Activity Lysosomal Membrane Viral Process Negative Regulation Of MiRNA Transcription Viral Release From Host Cell Late Endosome Membrane Organelle Organization Ubiquitin Conjugating Enzyme Activity Transport Along Microtubule Vesicle Budding From Membrane Organelle Localization Lysosome Supramolecular Fiber Organization Protein Targeting Anterograde Axonal Transport Positive Regulation Of Protein Catabolic Process Microtubule-based Transport	HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex
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