VPS41 and RAB7A

Number of citations: 51 (PubMedID 34432599)
Data Source: BioGRID (pull down, affinity chromatography technology, proximity labelling technology)

		VPS41	RAB7A
Name		VPS41 subunit of HOPS complex	RAB7A, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Cytosol Endosome Membrane Microtubule Cytoskeleton Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Clathrin Complex Lysosomal HOPS Complex	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding
	Biological Process	Protein Targeting To Vacuole Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Protein Transport Vesicle-mediated Transport Macroautophagy Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Golgi Vesicle Transport Late Endosome To Lysosome Transport	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		SARS-CoV-2 modulates autophagy	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs		None	Guanosine-5'-Diphosphate
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Breast cancer and/or colorectal cancer ( 29698419 ) Cognitive performance ( 19734545 )	Body fat mass ( 28552196 ) Facial morphology traits (63 three-dimensional facial segments) ( 29459680 )
Novel Interactors		2 novel interactors: ARID1A GSDME	8 novel interactors: COPG1 ENOPH1 FABP6 GP9 H1-10 RPN1 TMCC1 ZHX2
Interacting Genes		12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B	24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41
Entrez ID		27072	7879
HPRD ID		10402	03805
Ensembl ID		ENSG00000006715	ENSG00000075785
Uniprot IDs		P49754	A0A158RFU6 P51149
PDB IDs		Not available	1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3
GO Terms Enriched among Interactors		Endosome To Lysosome Transport Vacuolar Transport Early Endosome To Late Endosome Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Vesicle Organization HOPS Complex Endosomal Transport Vesicle-mediated Transport Intracellular Transport Endosome Organization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Lysosome Organization Vacuole Organization Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Protein Localization Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Presynaptic Endosome Cytoplasmic Microtubule Organization Microtubule-based Process Axo-dendritic Transport Protein Localization To Vacuole Phagosome-lysosome Fusion Neurotransmitter Receptor Transport Synaptic Vesicle Recycling Protein Localization To Organelle Ubiquitin-like Protein Transferase Activity Lysosomal Membrane Viral Process Negative Regulation Of MiRNA Transcription Viral Release From Host Cell Late Endosome Membrane Organelle Organization Ubiquitin Conjugating Enzyme Activity Transport Along Microtubule Vesicle Budding From Membrane Organelle Localization Lysosome Supramolecular Fiber Organization Protein Targeting Anterograde Axonal Transport Positive Regulation Of Protein Catabolic Process Microtubule-based Transport	Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion