VPS41 and RILP

Number of citations: 46 (PubMedID 25445562)
Data Source: BioGRID (pull down)

		VPS41	RILP
Name		VPS41 subunit of HOPS complex	Rab interacting lysosomal protein
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Cytosol Endosome Membrane Microtubule Cytoskeleton Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Clathrin Complex Lysosomal HOPS Complex	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Ciliary Basal Body
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Protein Binding Small GTPase Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Protein Targeting To Vacuole Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Protein Transport Vesicle-mediated Transport Macroautophagy Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Golgi Vesicle Transport Late Endosome To Lysosome Transport	Endosome To Lysosome Transport Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Protein Catabolic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Cilium Assembly Intralumenal Vesicle Formation
Pathways		SARS-CoV-2 modulates autophagy	MHC class II antigen presentation
GWAS		Breast cancer and/or colorectal cancer ( 29698419 ) Cognitive performance ( 19734545 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: ARID1A GSDME	None recorded
Interacting Genes		12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B	12 interacting genes: KPNA2 LDB2 RAB34 RAB7A RCHY1 SNF8 VPS11 VPS16 VPS18 VPS36 VPS39 VPS41
Entrez ID		27072	83547
HPRD ID		10402	09706
Ensembl ID		ENSG00000006715	ENSG00000167705
Uniprot IDs		P49754	Q96NA2
PDB IDs		Not available	1YHN
GO Terms Enriched among Interactors		Endosome To Lysosome Transport Vacuolar Transport Early Endosome To Late Endosome Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Vesicle Organization HOPS Complex Endosomal Transport Vesicle-mediated Transport Intracellular Transport Endosome Organization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Lysosome Organization Vacuole Organization Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Protein Localization Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Presynaptic Endosome Cytoplasmic Microtubule Organization Microtubule-based Process Axo-dendritic Transport Protein Localization To Vacuole Phagosome-lysosome Fusion Neurotransmitter Receptor Transport Synaptic Vesicle Recycling Protein Localization To Organelle Ubiquitin-like Protein Transferase Activity Lysosomal Membrane Viral Process Negative Regulation Of MiRNA Transcription Viral Release From Host Cell Late Endosome Membrane Organelle Organization Ubiquitin Conjugating Enzyme Activity Transport Along Microtubule Vesicle Budding From Membrane Organelle Localization Lysosome Supramolecular Fiber Organization Protein Targeting Anterograde Axonal Transport Positive Regulation Of Protein Catabolic Process Microtubule-based Transport	Vesicle Organization Late Endosome Membrane Vacuolar Transport Organelle Membrane Fusion Vesicle Fusion Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Endosome To Lysosome Transport Organelle Fusion Autophagy Late Endosome Membrane Fusion Intracellular Protein Transport Membrane Organization Protein Transport Lysosomal Transport Endosome Membrane Establishment Of Protein Localization Cellular Localization Vesicle-mediated Transport Endosome Intracellular Transport Intracellular Protein Localization Lysosome CORVET Complex AP-3 Adaptor Complex Establishment Of Localization In Cell Establishment Of Protein Localization To Vacuole Lysosomal Membrane Clathrin-coated Vesicle Organelle Organization Endosome Organization Protein Localization To Vacuole Catabolic Process Lysosomal HOPS Complex Endosomal Transport ESCRT II Complex Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Organelle Vesicle Tethering Complex Macroautophagy Vacuole Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Cytoplasmic Vesicle Endocytic Recycling Autophagosome Phagosome Maturation Membrane Docking