CS and CRYAA

Number of citations of the paper that reports this interaction (PMID 11377425)
15

Data Source:
HPRD (in vitro)

		CS	CRYAA
Gene Name		citrate synthase	crystallin, alpha A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome	Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Citrate (Si)-synthase Activity Poly(A) RNA Binding	Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Response To Stimulus Protein Homooligomerization
Pathways		Mitochondrial protein import Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS		Height ( 23456168)
Protein-Protein Interactions		5 interactors: CRYAA CRYAB DYNLL1 HSPB1 MDH2	17 interactors: ALB BCL2L1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP SDCBP SPG21 WDYHV1
Entrez ID		1431	1409
HPRD ID		00349	00427
Ensembl ID		ENSG00000062485	ENSG00000160202
Uniprot IDs		B4DJV2 O75390	E9PHE4 P02489
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Intracellular Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Cellular Localization Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Protein Homooligomerization Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process NADH Metabolic Process Protein Oligomerization Oxaloacetate Metabolic Process Malate Metabolic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Development Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Substantia Nigra Development Platelet Aggregation Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Catalytic Activity Tricarboxylic Acid Cycle Cellular Response To Vascular Endothelial Growth Factor Stimulus	Visual Perception Sensory Perception Of Light Stimulus Camera-type Eye Development Eye Development Lens Development In Camera-type Eye Sensory Organ Development Sensory Perception Cellular Response To Gamma Radiation Neurological System Process Bile Acid And Bile Salt Transport Response To Gamma Radiation Cellular Response To Ionizing Radiation Apoptotic Process In Bone Marrow Retina Homeostasis Maintenance Of Mitochondrion Location Lactose Biosynthetic Process Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus Interaction With Host Organ Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Suppression By Virus Of Host Apoptotic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Disaccharide Metabolic Process Canalicular Bile Acid Transport Positive Regulation Of Behavior Monocarboxylic Acid Transport Response To Unfolded Protein Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Cell Death Cellular Response To Radiation System Development Response To Ionizing Radiation Protein Processing Involved In Protein Targeting To Mitochondrion Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Stress
Tagcloud ?		ampar asparagine biionic ca2 channels equation exponent externally fluorometric flux glur glurs goldman hek hodgkin internally isoxazolepropionate katz nmdar overload pca pcs permeability permeable permeant q quantifying reflects transports	aiims beaded bfsp1 cataract congenital cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Difference) ?		ampar asparagine biionic ca2 channels equation exponent externally fluorometric flux glur glurs goldman hek hodgkin internally isoxazolepropionate katz nmdar overload pca pcs permeability permeable permeant q quantifying reflects transports	aiims beaded bfsp1 cataract congenital cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Intersection) ?