CS and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 11377425)
0

Data Source:
HPRD (in vitro)

		CS	CRYAA
Description		citrate synthase	crystallin alpha A
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Binding Transferase Activity Citrate Synthase Activity Identical Protein Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways		Mitochondrial protein import Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Trifluoroacetonyl coenzyme A Coenzyme A Oxaloacetate Ion alpha-Fluoro-carboxymethyldethia coenzyme A complex D-Malic acid Nitromethyldethia coenzyme A Citric acid
Diseases
GWAS		Height ( 23456168 31562340 34270706) Inflammatory skin disease ( 25574825) Refractive error ( 32231278)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		8 interacting genes: CRYAA CRYAB DYNLL1 HSD17B10 HSPB1 LCOR LINC01554 MDH2	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		1431	1409
HPRD ID		00349	00427
Ensembl ID		ENSG00000062485	ENSG00000160202
Uniprot IDs		O75390	A0A8C8KJZ9 P02489
PDB IDs		5UZP 5UZQ 5UZR	6T1R
Enriched GO Terms of Interacting Partners?		Protein Refolding Tubulin Complex Assembly Response To Heat Unfolded Protein Binding Contractile Muscle Fiber Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Response To Temperature Stimulus Apoptotic Process Involved In Development Protein Folding Lens Development In Camera-type Eye Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Microtubule-based Process Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Protein Kinase C Signaling Axon Cytoplasm L-malate Dehydrogenase (NADP+) Activity Alkylglycerone-phosphate Synthase Activity Mitochondrion Camera-type Eye Development Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Response To Hydrogen Peroxide Response To Estradiol Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Protein Kinase C Inhibitor Activity L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Eye Development Regulation Of Cellular Localization Z Disc Mitochondrial RNA 5'-end Processing Isoleucine Metabolic Process L-isoleucine Catabolic Process Regulation Of Protein Kinase C Signaling Response To Reactive Oxygen Species TRNA Methyltransferase Complex	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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