CS and DYNLL1

Number of citations of the paper that reports this interaction (PMID 14760703)
24

Data Source:
HPRD (in vitro)

		CS	DYNLL1
Gene Name		citrate synthase	dynein, light chain, LC8-type 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip
	Molecular Function	Citrate (Si)-synthase Activity Poly(A) RNA Binding	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Mitochondrial protein import Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Height ( 23456168)
Protein-Protein Interactions		5 interactors: CRYAA CRYAB DYNLL1 HSPB1 MDH2	77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A
Entrez ID		1431	8655
HPRD ID		00349	03334
Ensembl ID		ENSG00000062485	ENSG00000088986
Uniprot IDs		B4DJV2 O75390	P63167 Q6FGH9
PDB IDs			1CMI 3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Intracellular Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Cellular Localization Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Protein Homooligomerization Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process NADH Metabolic Process Protein Oligomerization Oxaloacetate Metabolic Process Malate Metabolic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Development Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Substantia Nigra Development Platelet Aggregation Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Catalytic Activity Tricarboxylic Acid Cycle Cellular Response To Vascular Endothelial Growth Factor Stimulus	Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process
Tagcloud ?		ampar asparagine biionic ca2 channels equation exponent externally fluorometric flux glur glurs goldman hek hodgkin internally isoxazolepropionate katz nmdar overload pca pcs permeability permeable permeant q quantifying reflects transports	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		ampar asparagine biionic ca2 channels equation exponent externally fluorometric flux glur glurs goldman hek hodgkin internally isoxazolepropionate katz nmdar overload pca pcs permeability permeable permeant q quantifying reflects transports	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?