CS and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 22496890)
28

Data Source:
BioGRID (two hybrid, proximity labelling technology, proximity labelling technology)

		CS	HSD17B10
Description		citrate synthase	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex
	Molecular Function	RNA Binding Transferase Activity Citrate Synthase Activity Identical Protein Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer	TRNA Binding RNA Binding (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Cholate 7-alpha-dehydrogenase (NAD+) Activity Oxidoreductase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process	L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization TRNA Processing Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Mitochondrial protein import Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion Mitochondrial protein degradation
Drugs		Trifluoroacetonyl coenzyme A Coenzyme A Oxaloacetate Ion alpha-Fluoro-carboxymethyldethia coenzyme A complex D-Malic acid Nitromethyldethia coenzyme A Citric acid	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases			Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH) 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
GWAS		Height ( 23456168 31562340 34270706) Inflammatory skin disease ( 25574825) Refractive error ( 32231278)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		8 interacting genes: CRYAA CRYAB DYNLL1 HSD17B10 HSPB1 LCOR LINC01554 MDH2	30 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHB PDHX PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		1431	3028
HPRD ID		00349	02223
Ensembl ID		ENSG00000062485	ENSG00000072506
Uniprot IDs		O75390	A0A0S2Z410 Q99714
PDB IDs		5UZP 5UZQ 5UZR	1SO8 1U7T 2O23 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH
Enriched GO Terms of Interacting Partners?		Protein Refolding Tubulin Complex Assembly Response To Heat Unfolded Protein Binding Contractile Muscle Fiber Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Response To Temperature Stimulus Apoptotic Process Involved In Development Protein Folding Lens Development In Camera-type Eye Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Microtubule-based Process Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Protein Kinase C Signaling Axon Cytoplasm L-malate Dehydrogenase (NADP+) Activity Alkylglycerone-phosphate Synthase Activity Mitochondrion Camera-type Eye Development Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Response To Hydrogen Peroxide Response To Estradiol Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Protein Kinase C Inhibitor Activity L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Eye Development Regulation Of Cellular Localization Z Disc Mitochondrial RNA 5'-end Processing Isoleucine Metabolic Process L-isoleucine Catabolic Process Regulation Of Protein Kinase C Signaling Response To Reactive Oxygen Species TRNA Methyltransferase Complex	Mitochondrion Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Mitochondrial Matrix TOM Complex Tricarboxylic Acid Cycle Mitochondrial Outer Membrane Translocase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Protein Insertion Into Mitochondrial Outer Membrane Catabolic Process Carboxylic Acid Catabolic Process Organophosphate Metabolic Process Oxidoreductase Activity Glutamine Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Inner Membrane Protein Import Into Mitochondrial Matrix Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Protein Transmembrane Transporter Activity Generation Of Precursor Metabolites And Energy Purine-containing Compound Metabolic Process Catalytic Activity Dicarboxylic Acid Metabolic Process Protein Targeting To Mitochondrion Acyl-CoA Metabolic Process Acetyl-CoA Metabolic Process Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Ketone Body Biosynthetic Process Mitochondrion Targeting Sequence Binding Organophosphate Biosynthetic Process Cytoplasmic Side Of Plasma Membrane Nucleoside Phosphate Metabolic Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Interleukin-17A-mediated Signaling Pathway Protein Localization To Mitochondrion Neuron Projection Organization Enoyl-CoA Hydratase Activity Pyruvate Decarboxylation To Acetyl-CoA Sulfur Compound Metabolic Process Midgut Development Mitochondrial Nucleoid L-glutamate Catabolic Process
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