LALBA and HIST2H2BE

Number of citations of the paper that reports this interaction (PMID 12888554)
10

Data Source:
HPRD (in vitro)

		LALBA	HIST2H2BE
Gene Name		lactalbumin, alpha-	histone cluster 2, H2be
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Lactose Synthase Activity Calcium Ion Binding	DNA Binding Protein Heterodimerization Activity
	Biological Process	Lactose Biosynthetic Process Apoptotic Process Signal Transduction Cell-cell Signaling Defense Response To Bacterium	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: B4GALT1 CRYAA CRYAB HIST2H2BE HIST2H3A HSPA8 UBC	74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1
Entrez ID		3906	8349
HPRD ID		01024	03494
Ensembl ID		ENSG00000167531	ENSG00000184678
Uniprot IDs		P00709	Q16778
PDB IDs		1A4V 1B9O 1CB3 1HML 3B0I 3B0O 4L41
Enriched GO Terms of Interacting Partners?		Response To Stress Negative Regulation Of Fibril Organization Regulation Of Apoptotic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Regulation Of Cell Death Response To Stimulus Notch Signaling Pathway Regulation Of Fibril Organization Lactose Biosynthetic Process Carbohydrate Biosynthetic Process Clathrin Coat Disassembly Pathogenesis Hexose Metabolic Process Disaccharide Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process MAPK Cascade Negative Regulation Of Programmed Cell Death Cellular Carbohydrate Metabolic Process Negative Regulation Of Cell Death Tubulin Complex Assembly Penetration Of Zona Pellucida Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Monosaccharide Metabolic Process Protein Homooligomerization Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Complex Assembly Regulation Of Cellular Localization Signal Transduction By Phosphorylation Protein Folding Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Acrosome Reaction Viral Protein Processing Negative Regulation Of RNA Biosynthetic Process DNA Methylation On Cytosine Development Of Secondary Sexual Characteristics Chromatin Silencing At RDNA Negative Regulation Of Gene Expression Innate Immune Response In Mucosa Defense Response Negative Regulation Of Biosynthetic Process Oligosaccharide Biosynthetic Process Negative Regulation Of Transport Chaperone Mediated Protein Folding Requiring Cofactor Apoptotic Process Involved In Morphogenesis	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation
Tagcloud ?		casein concentration csn1s1 csn1s2 csn2 csn3 driven elf5 factorial focusing greatest incubated jak lys met methionine milk mm mtor optimum peak peaked ppm preliminary rapamycin stat stat5 supplemental upregulation	5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis
Tagcloud (Difference) ?		casein concentration csn1s1 csn1s2 csn2 csn3 driven elf5 factorial focusing greatest incubated jak lys met methionine milk mm mtor optimum peak peaked ppm preliminary rapamycin stat stat5 supplemental upregulation	5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis
Tagcloud (Intersection) ?