LALBA and B4GALT1

Number of citations of the paper that reports this interaction (PMID 11947697)
10

Data Source:
HPRD (in vitro)

		LALBA	B4GALT1
Gene Name		lactalbumin, alpha-	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Glycocalyx Filopodium Brush Border Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	Lactose Synthase Activity Calcium Ion Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Protein Homodimerization Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Lactose Biosynthetic Process Apoptotic Process Signal Transduction Cell-cell Signaling Defense Response To Bacterium	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Notch Signaling Pathway Single Fertilization Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Proliferation Oligosaccharide Biosynthetic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Mammary Gland Development Multicellular Organism Reproduction Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Development Of Secondary Sexual Characteristics Branching Morphogenesis Of An Epithelial Tube Leukocyte Migration Regulation Of Cellular Component Movement Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Pathways			Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Fertilization N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Interaction With The Zona Pellucida
Drugs			N-Acetyl-D-glucosamine 6-Aminohexyl-Uridine-C1,5\'-Diphosphate Di(N-Acetyl-D-Glucosamine) Uridine Diphosphate Galactose Uridine-5\'-Monophosphate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS			IgG glycosylation ( 23382691) Urate levels ( 23263486)
Protein-Protein Interactions		7 interactors: B4GALT1 CRYAA CRYAB HIST2H2BE HIST2H3A HSPA8 UBC	6 interactors: CDK11A LALBA TFRC TUBA1A TUBA4A TUBB
Entrez ID		3906	2683
HPRD ID		01024	00659
Ensembl ID		ENSG00000167531	ENSG00000086062
Uniprot IDs		P00709	P15291
PDB IDs		1A4V 1B9O 1CB3 1HML 3B0I 3B0O 4L41	2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41
Enriched GO Terms of Interacting Partners?		Response To Stress Negative Regulation Of Fibril Organization Regulation Of Apoptotic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Regulation Of Cell Death Response To Stimulus Notch Signaling Pathway Regulation Of Fibril Organization Lactose Biosynthetic Process Carbohydrate Biosynthetic Process Clathrin Coat Disassembly Pathogenesis Hexose Metabolic Process Disaccharide Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process MAPK Cascade Negative Regulation Of Programmed Cell Death Cellular Carbohydrate Metabolic Process Negative Regulation Of Cell Death Tubulin Complex Assembly Penetration Of Zona Pellucida Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Monosaccharide Metabolic Process Protein Homooligomerization Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Complex Assembly Regulation Of Cellular Localization Signal Transduction By Phosphorylation Protein Folding Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Acrosome Reaction Viral Protein Processing Negative Regulation Of RNA Biosynthetic Process DNA Methylation On Cytosine Development Of Secondary Sexual Characteristics Chromatin Silencing At RDNA Negative Regulation Of Gene Expression Innate Immune Response In Mucosa Defense Response Negative Regulation Of Biosynthetic Process Oligosaccharide Biosynthetic Process Negative Regulation Of Transport Chaperone Mediated Protein Folding Requiring Cofactor Apoptotic Process Involved In Morphogenesis	Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Interleukin-4 Cell Cycle Process Cellular Protein Complex Assembly Response To Interleukin-4 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Microtubule Cytoskeleton Organization Cell Cycle Cellular Macromolecular Complex Assembly Lactose Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Disaccharide Metabolic Process Protein Complex Assembly Cytoskeleton Organization Protein Folding Iron Ion Import Organelle Organization Positive Regulation Of Bone Resorption Oligosaccharide Biosynthetic Process Cell Division Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Positive Regulation Of Tissue Remodeling Transferrin Transport Leukocyte Mediated Cytotoxicity Cellular Component Assembly Cellular Response To Cytokine Stimulus Regulation Of Bone Resorption Establishment Of Localization In Cell Regulation Of Bone Remodeling Osteoclast Differentiation Response To Cytokine Oligosaccharide Metabolic Process Cellular Response To Drug Cellular Localization Regulation Of Tissue Remodeling
Tagcloud ?		casein concentration csn1s1 csn1s2 csn2 csn3 driven elf5 factorial focusing greatest incubated jak lys met methionine milk mm mtor optimum peak peaked ppm preliminary rapamycin stat stat5 supplemental upregulation	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Difference) ?		casein concentration csn1s1 csn1s2 csn2 csn3 driven elf5 factorial focusing greatest incubated jak lys met methionine milk mm mtor optimum peak peaked ppm preliminary rapamycin stat stat5 supplemental upregulation	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Intersection) ?